Brad Nolen

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Publications (26)

• Direct Actin Monomer Delivery is a WASP-specific Requirement for Arp2/3 Complex Activation
  Journal of Molecular Biology 2026 DOI: 10.1016/j.jmb.2026.169662
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• Activation of Arp2/3 complex by a SPIN90 dimer in linear actin-filament nucleation
  Justus Francis, Achyutha Krishna Pathri, Kankipati Teja Shyam

  +6 more

  • Sridhar Sripada
  • Rishav Mitra
  • Heidy Y. Narvaez‐Ortiz
  • Kiran Vyshnav Eliyan
  • Brad J. Nolen
  • +1 more
  Nature Structural & Molecular Biology 2025 DOI: 10.1038/s41594-025-01673-8
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• The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton
  eLife 2023 DOI: 10.7554/eLife.88492
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• Structure of Arp2/3 complex at a branched actin filament junction resolved by single-particle cryo-electron microscopy
  Bojian Ding, Heidy Y. Narvaez‐Ortiz, Yuvraj Singh +3 more
  Proceedings of the National Academy of Sciences 2022 DOI: 10.1073/pnas.2202723119
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• Unconcerted conformational changes in Arp2/3 complex integrate multiple activating signals to assemble functional actin networks
  Current Biology 2022 DOI: 10.1016/j.cub.2022.01.004
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• Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks
  eLife 2020 DOI: 10.7554/eLife.60419
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• Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state
  Mohammed Shaaban, Saikat Chowdhury, Brad J. Nolen
  Nature Structural & Molecular Biology 2020 DOI: 10.1038/s41594-020-0481-x
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• Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks
  2020 DOI: 10.1101/2020.07.03.187120
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• Structure of the nucleation‐promoting factor SPIN 90 bound to the actin filament nucleator Arp2/3 complex
  The EMBO Journal 2018 DOI: 10.15252/embj.2018100005
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• Identification of Wiskott-Aldrich syndrome protein (WASP) binding sites on the branched actin filament nucleator Arp2/3 complex
  Proceedings of the National Academy of Sciences 2018 DOI: 10.1073/pnas.1716622115
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• Dip1 Co-opts Features of Branching Nucleation to Create Linear Actin Filaments that Activate WASP-Bound Arp2/3 Complex
  Current Biology 2018 DOI: 10.1016/j.cub.2018.10.045
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• Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex
  Nature Communications 2016 DOI: 10.1038/ncomms12226
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• Role and structural mechanism of WASP-triggered conformational changes in branched actin filament nucleation by Arp2/3 complex
  Proceedings of the National Academy of Sciences 2016 DOI: 10.1073/pnas.1517798113
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• Interactions with Actin Monomers, Actin Filaments, and Arp2/3 Complex Define the Roles of WASP Family Proteins and Cortactin in Coordinately Regulating Branched Actin Networks
  Journal of Biological Chemistry 2014 DOI: 10.1074/jbc.m114.587527
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• Dip1 Defines a Class of Arp2/3 Complex Activators that Function without Preformed Actin Filaments
  Current Biology 2013 DOI: 10.1016/j.cub.2013.08.029
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• Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP.
  eLife 2013 DOI: 10.7554/eLife.00884
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• Structural basis for regulation of Arp2/3 complex by GMF.
  Nature structural & molecular biology 2013 DOI: 10.1038/nsmb.2628
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• Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change
  Chemistry & Biology 2013 DOI: 10.1016/j.chembiol.2013.03.019
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• Insertions within the Actin Core of Actin-related Protein 3 (Arp3) Modulate Branching Nucleation by Arp2/3 Complex
  Journal of Biological Chemistry 2012 DOI: 10.1074/jbc.m112.406744
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• Structural Characterization and Computer-Aided Optimization of a Small-Molecule Inhibitor of the Arp2/3 Complex, a Key Regulator of the Actin Cytoskeleton
  ChemMedChem 2012 DOI: 10.1002/cmdc.201200104
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