JL
Ju-hyun Lee
New York University Langone Medical Center, NYU School of Medicine, Institute of Psychiatry at the Maudsley, Nathan S Kline Institute
0000-0002-0280-8375
Employment
-
New York University Langone Medical Center Assistnat Professor2014 - Present
-
NYU School of Medicine Research Assistant Professor of Psychiatry (Academic)2005 - Present
-
Nathan S Kline Institute2004 - Present
Education
-
Institute of Psychiatry at the Maudsley Ph.D2000 - 2004
Projects & Funding
Projects & funding information is unavailable.
Publications (25)
- Autophagy-lysosomal dysfunction, intraneuronal amyloidosis, and selective neuron death yield senile plaques in preclinical late-onset Alzheimer’s Disease Save
- Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr 682 -phosphorylated APP βCTF Save
- Autophagy is a novel pathway for neurofilament protein degradation in vivo Save
- Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis Save
- Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques Save
- Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca 2+ efflux and disrupted by PSEN1 loss of function Save
- Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease Save
- β2-adrenergic Agonists Rescue Lysosome Acidification and Function in Psen1 Deficiency by Reversing Defective Er-to-lysosome Delivery of Clc-7 Save
- Endosomal Dysfunction Induced by Directly Over-Activating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease Save
- Transgenic Expression of a Ratiometric Autophagy Probe Specifically in Neurons Enables the Interrogation of Brain Autophagy in Vivo Save