Sumedh Varad Joshi

Employment

Employment history is unavailable.

Education

• American Chemical Society ACS Reviewer Lab Certificate of Completion
• American Chemical Society ACS Reviewer Lab Certificate of Completion

Projects & Funding

Projects & funding information is unavailable.

Publications (9)

• Phosphomethylpyrimidine Synthase (ThiC): Trapping of Five Intermediates Provides Mechanistic Insights on a Complex Radical Cascade Reaction in Thiamin Biosynthesis
  ACS Central Science 2024 DOI: 10.1021/acscentsci.4c00125
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• Menaquinone Biosynthesis: The Mechanism of 5,8-Dihydroxy-2-naphthoate Synthase (MqnD)
  Biochemistry 2021 DOI: 10.1021/acs.biochem.1c00257
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• Menaquinone Biosynthesis: New Strategies to Trap Radical Intermediates in the MqnE-Catalyzed Reaction
  Biochemistry 2021 DOI: 10.1021/acs.biochem.1c00181
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• Radical SAM Enzyme HydE Generates Adenosylated Fe(I) Intermediates En Route to the [FeFe]-Hydrogenase Catalytic H‑Cluster
  Journal of the American Chemical Society 2020 DOI: 10.1021/jacs.0c03802
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• Trapping and Electron Paramagnetic Resonance Characterization of the 5′dAdo• Radical in a Radical S-Adenosyl Methionine Enzyme Reaction with a Non-Native Substrate
  ACS Central Science 2019 DOI: 10.1021/acscentsci.9b00706
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• Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis
  ACS Medicinal Chemistry Letters 2019 DOI: 10.1021/acsmedchemlett.8b00649
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• Novel enzymology in futalosine-dependent menaquinone biosynthesis
  Current Opinion in Chemical Biology 2018 DOI: 10.1016/j.cbpa.2018.09.015
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• Aminofutalosine Synthase (MqnE): A New Catalytic Motif in Radical SAM Enzymology
  Methods in Enzymology 2018 DOI: 10.1016/bs.mie.2018.05.002
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• Aminofutalosine Synthase: Evidence for Captodative and Aryl Radical Intermediates Using β-Scission and SRN1 Trapping Reactions
  Journal of the American Chemical Society 2017 DOI: 10.1021/jacs.7b04209
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