Aditya Sarode
Columbia University, National Centre for Cell Science, ICMR-National Institute of Virology, Savitribai Phule Pune University
Research areas: Medicine · Public Health, Environmental and Occupational Health · Research on Leishmaniasis Studies · Leprosy Research and Treatment · T-cell and B-cell Immunology
0000-0002-0685-4942
About
I am a Postdoctoral Research Scientist at the Columbia University Irving Medical Center where I am understanding the mechanism of AICDA, a DNA mutator with paramount importance in antibody diversity in on-target activity using human B cells. I am studying this by targeting the degradation of essential proteins using a state-of-the-art technology called the Degron system which is generated using knockin and single-cell cloning. These targets were identified from mass spec and mutations seen in DHL and DLBCL a form of B-cell lymphoma.
During my Ph.D. I delineated interaction between CD40L- CD40 during a macrophage T cell interaction using residue-specific functions on CD40L which are reported in hyper IgM syndrome. While studying this I also generated avirulent strains of Leishmania parasites which we tested as a vaccine strain in different knockout mice and studied the immune response elicited by this vaccine. I also developed a DNA vaccine against one of the target proteins in Leishmania and tested it. During my master's in Virology from the National Institute of Virology, Pune I study different classes of virus and their pathogenesis. In particular, I studied the role of host kinases in the pathogenesis of the Japanese Encephalitis virus for my master's dissertation. I have a deep understanding of Immunology, APC-Tcell interaction, host-pathogen interactions, RNA biology, Bcell biology, and vaccines. My area of interest is immunology, tumor immunology, macrophages, B cells, host-pathogen interactions, virology, RNA biology, and cancer biology.
Employment
-
Columbia University Postdoctoral Research Scientist2021 - Present
-
National Centre for Cell Science Senior Research Fellow2017 - 2020
Education
- 2014 - 2020
-
National Institute of Virology Masters in Virology2008 - 2010
-
Savitribai Phule Pune University Bachelors in Biotechnology2005 - 2008
Projects & Funding
Projects & funding information is unavailable.
Publications (17)
- An Overview of Latest Developments in DLBCL its Pathogenesis, Immune Significance, Prognosis and Targets Save
- Leishmania major MAPK4 intercepts and redirects CD40 signaling promoting infection Save
- The Role of Cancer-Specific Target Antigens in CAR T Cell Therapy in Hematological Malignancies Save
- Interleukin-7 potentiates MAPK10-elicited host-protective vaccine against Leishmania donovani Save
- Myotubularin-related protein-6 silencing protects mice from Leishmania donovani infection. Save
- Neutrophils at the Crossroads: Unraveling the Multifaceted Role in the Tumor Microenvironment Save
- Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression Save
- LmjF.36.3850, a novel hypothetical Leishmania major protein, contributes to the infection Save
- Single Receptor reciprocity as message encrypted in CD40-ligand Save
- Leishmania majoradenylate kinase immunization offers partial protection to a susceptible host Save
- Ras isoforms selectively regulate antigen-specific immune response Save
- A Leishmania donovani dominant‐negative mutant for eIF2α kinase LdeK1 elicits host‐protective immune response Save
- Barley beta-Glucan and Zymosan induce Dectin-1 and Toll-like receptor 2 co-localization and anti-leishmanial immune response in Leishmania donovani-infected BALB/c mice Save
- Development and Characterization of an Avirulent Leishmania major Strain Save
- Residue-Specific Message Encoding in CD40-Ligand Save
- Residue-Specific Message Encryption in CD40-Ligand Save
- DAMP-TLR-cytokine axis dictates the fate of tumor Save