CL
Ciaran Lee
University College Cork, Rice University, University College Cork APC Microbiome Institute
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · CRISPR and Genetic Engineering · Virus-based gene therapy research · RNA regulation and disease
0000-0002-0789-9149
Employment
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University College Cork Lecturer2023 - Present
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University College Cork Research Support Officer2023 - 2023
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University College Cork Marie Curie Research Fellow2021 - 2023
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Rice University Visiting Scholar2019 - 2024
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University College Cork APC Microbiome Institute Senior Postdoctoral Fellow2019 - 2021
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Rice University Director Genome Editing Core2015 - 2018
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Georgia Institute of Technology Postdoctoral Scholar2013 - 2015
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University College Cork Postdoctoral Fellow2010 - 2012
Education
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University College Cork PhD Medicine2006 - 2011
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University College Cork BSc Genetics2002 - 2006
Projects & Funding
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Bifidobacteria as a model system for host-microbe interaction H2020 Marie Skłodowska-Curie Actions2021 - 2023
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Cystinosis Gene Repair Cystinosis Research Foundation2010 - 2012
Publications (92)
- Insights into the Mechanism of Allele Conversion using a Fluorescent Reporter-Based Compound Heterozygous Allele Conversion Reporter (CHACR) Cell Line Model Save
- Haplotype-Embedded Regulatory Variation Shapes Gene Expression and Immune Associations Save
- A <scp>CRISPRi</scp> Gene Regulation System for Bifidobacteria Save
- Generation of Region-specific Airway Basal Stem Cells from Human Pluripotent Stem Cells via Regulation of BMP-NOGGIN Axis Save
- Off-target effects in CRISPR-Cas genome editing for human therapeutics Save
- Deep Learning Based Models for CRISPR/Cas Off-Target Prediction Save
- Genetic Characterisation of the upp Gene in Bifidobacterium bifidum PRL2010 Save
- Improving resolution with single-cell detection of CRISPR off-target events Save
- IL-32 drives inflammatory responses in IFN-γ primed human macrophages via a Myddosome-dependent pathway and is elevated in COVID-19 Save
- An Overview and Comparative Analysis of CRISPR-SpCas9 gRNA Activity Prediction Tools Save
- Haplotype rather than single causal variants effects contribute to regulatory gene expression associations in human myeloid cells Save
- Pseudocin 196, a novel lantibiotic produced by Bifidobacterium pseudocatenulatum elicits antimicrobial activity against clinically relevant pathogens Save
- Gene editing-based targeted integration for correction of Wiskott-Aldrich syndrome Save
- GH136‐encoding gene (perB) is involved in gut colonization and persistence by Bifidobacterium bifidumPRL2010 Save
- Two extracellular α-arabinofuranosidases are required for cereal-derived arabinoxylan metabolism by Bifidobacterium longum subsp. longum Save
- Electroporation-Mediated Delivery of Cas9 Ribonucleoproteins Results in High Levels of Gene Editing in Primary Hepatocytes Save
- High-Throughput Imaging of CRISPR- and Recombinant Adeno-Associated Virus-Induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells. Save
- Identification and Validation of CRISPR/Cas9 Off-Target Activity in Hematopoietic Stem and Progenitor Cells. Save
- In vivo genome editing at the albumin locus to treat methylmalonic acidemia Save
- TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells Save