Claus Hallwirth

Employment

• Children's Medical Research Institute Senior Research Officer
  2009 - Present
• Victor Chang Cardiac Research Institute Post-doctoral scientist
  2006 - 2009
• Molecular Diagnostic Services Molecular biological research scientist
  2005 - 2006

Education

• University of KwaZulu-Natal - Pietermaritzburg Campus B.Sc.Agric
  1994 - 1997
• University of KwaZulu-Natal PhD
  ? - 2008

Projects & Funding

Projects & funding information is unavailable.

Publications (14)

• Restoring the natural tropism of AAV2 vectors for human liver
  Science Translational Medicine 2020 DOI: 10.1126/scitranslmed.aba3312
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• Efficient in vivo editing of OTC-deficient patient-derived primary human hepatocytes
  JHEP Reports 2020 DOI: 10.1016/j.jhepr.2019.100065
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• Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality.
  Molecular therapy. Methods & clinical development 2018 DOI: 10.1016/j.omtm.2018.10.016
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• Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome.
  Nature genetics 2017 DOI: 10.1038/ng.3893
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• Ub-ISAP: a streamlined UNIX pipeline for mining unique viral vector integration sites from next generation sequencing data.
  BMC bioinformatics 2017 DOI: 10.1186/s12859-017-1719-4
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• Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency.
  Molecular therapy. Nucleic acids 2016 DOI: 10.1016/j.omtn.2016.11.011
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• Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus.
  Scientific reports 2016 DOI: 10.1038/srep28965
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• Modeling correction of severe urea cycle defects in the growing murine liver using a hybrid recombinant adeno-associated virus/piggyBac transposase gene delivery system.
  Hepatology (Baltimore, Md.) 2015 DOI: 10.1002/hep.27842
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• Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditions.
  Molecular therapy. Methods & clinical development 2015 DOI: 10.1038/mtm.2015.15
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• Probing the closed-loop model of mRNA translation in living cells.
  RNA biology 2015 DOI: 10.1080/15476286.2015.1017242
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• Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence.
  Claire T. Deakin, Jeffrey John Deakin, Samantha L. Ginn +5 more
  Nucleic acids research 2014 DOI: 10.1093/nar/gku607
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• A Moloney murine leukemia virus driven by the Jaagsiekte sheep retrovirus enhancers shows enhanced specificity for infectivity in lung epithelial cells.
  Virus genes 2005 DOI: 10.1007/s11262-005-3239-y
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• Variable regions 1 and 2 (VR1 and VR2) in JSRV gag are not responsible for the endogenous JSRV particle release defect.
  Virus genes 2005 DOI: 10.1007/s11262-004-4582-0
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• Molecular cloning and functional analysis of three type D endogenous retroviruses of sheep reveal a different cell tropism from that of the highly related exogenous jaagsiekte sheep retrovirus.
  Journal of virology 2000 DOI: 10.1128/jvi.74.17.8065-8076.2000
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