Sarath Ramachandran

Employment

• University of Dundee Senior Drug Discovery Scientist
  2022 - Present
• University of Dundee Postdoctoral Research Scientist
  2017 - 2022
• National University of Singapore Research Assistant
  2016 - 2017

Education

• National University of Singapore Doctor of Philosophy
  2011 - 2016
• Indian Institute of Technology Guwahati Master of Technology
  2009 - 2011

Projects & Funding

Projects & funding information is unavailable.

Publications (9)

• Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders
  2024 DOI: 10.1101/2024.01.17.575503
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• Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2
  Nature Communications 2023 DOI: 10.1038/s41467-023-41894-3
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• HiBiT Cellular Thermal Shift Assay (HiBiT CETSA)
  Methods in Molecular Biology 2023 DOI: 10.1007/978-1-0716-3397-7_11
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• Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues
  Current Opinion in Structural Biology 2021 DOI: 10.1016/j.sbi.2020.10.009
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• Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase
  Nature Communications 2019 DOI: 10.1038/s41467-019-10190-4
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• Structural basis for exploring the allosteric inhibition of human kidney type glutaminase
  2016 DOI: 10.18632/oncotarget.10791
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• Structure and mapping of spontaneous mutational sites of PyrR from Mycobacterium tuberculosis
  Biochemical and Biophysical Research Communications 2016 DOI: 10.1016/j.bbrc.2016.02.071
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• Structural basis of mapping the spontaneous mutations with 5-flurouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosis
  Biochemical and Biophysical Research Communications 2015 DOI: 10.1016/j.bbrc.2015.09.133
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• Dimeric Switch of Hakai-truncated Monomers during Substrate Recognition
  Journal of Biological Chemistry 2014 DOI: 10.1074/jbc.m114.592840
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