Michael R. Duggan

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Publications (67)

• Alzheimer’s disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA
  Science Translational Medicine 2026 DOI: 10.1126/scitranslmed.adx4852
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• Plasma GDF15 affects long-term dementia risk and alters neuro-immune signaling
  Cassandra Blew, Michael R. Duggan, Dimitrios Tsitsipatis +49 more
  Science Advances 2026 DOI: 10.1126/sciadv.aec7614
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• The role of frailty and comorbidities in severe infections and the risk of dementia: a prospective, multicohort, observational study
  The Lancet Healthy Longevity 2026 DOI: 10.1016/j.lanhl.2026.100826
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• Can the COVID-19 pandemic advance neuroinfectious research?
  Brain, Behavior, and Immunity 2026 DOI: 10.1016/j.bbi.2025.106233
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• Accelerated multi-organ proteomic aging is detectable decades before dementia onset
  medRxiv 2026 DOI: 10.64898/2026.01.16.26344299
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• Blood-based proteomic signature of amyloidosis: identification of novel regulators of amyloid load
  ALZHEIMERS & DEMENTIA 2026 DOI: 10.1002/ALZ.71611
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• CMV titer associations with cognition and the plasma proteome implicate FLT1 and neurovascular mechanisms as potential moderators
  JOURNAL OF NEUROINFLAMMATION 2026 DOI: 10.1186/S12974-026-03800-8
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• Can infections drive frailty? Insights from the Baltimore Longitudinal Study of Aging
  JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 2026 DOI: 10.1093/GERONA/GLAG043
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• Can we refute a role for infections in Alzheimer's disease pathogenesis?
  ALZHEIMERS & DEMENTIA 2026 DOI: 10.1002/ALZ.71288
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• Coupled cross-sectional and longitudinal non-negative matrix factorization reveals dominant brain aging trajectories in 48,949 individuals
  NATURE COMMUNICATIONS 2026 DOI: 10.1038/S41467-026-72091-7
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• MRI-based multi-organ clocks for healthy aging and disease assessment
  NATURE MEDICINE 2026 DOI: 10.1038/S41591-025-03999-8
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• Multi-omics validation of myelin water fraction as a myelin-specific MRI biomarker
  NEUROIMAGE 2026 DOI: 10.1016/J.NEUROIMAGE.2026.121852
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• Multi-organ AI endophenotypes chart the heterogeneity of brain, eye and heart pan-disease
  NATURE MENTAL HEALTH 2026 DOI: 10.1038/S44220-025-00560-X
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• OMG! A proteomic determinant of neurodegenerative resiliency
  MOLECULAR NEURODEGENERATION 2026 DOI: 10.1186/S13024-025-00921-1
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• Sleep chart of biological ageing clocks in middle and late life
  NATURE 2026 DOI: 10.1038/S41586-026-10524-5
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• Post-infection brain atrophy accelerates cognitive and molecular changes underlying dementia
  Alzheimer's Research & Therapy 2025 DOI: 10.1186/s13195-025-01924-2
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• Brain–heart–eye axis revealed by multi-organ imaging genetics and proteomics
  Nature Biomedical Engineering 2025 DOI: 10.1038/s41551-025-01506-5
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• Plasma proteomic signatures of dual cognitive and mobility decline in older adults
  eBioMedicine 2025 DOI: 10.1016/j.ebiom.2025.105858
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• Plasma GDF15 affects long-term dementia risk and alters neuro-immune signaling
  2025 DOI: 10.1101/2025.07.18.25331297
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• Proteomic signatures of corona and herpes viral antibodies identify IGDCC4 as a mediator of neurodegeneration
  Michael R. Duggan, Shuojia Yang, Gabriela Gómez +30 more
  Science Advances 2025 DOI: 10.1126/sciadv.adt7176
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