Karl Fraser
University of Auckland
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Metabolomics and Mass Spectrometry Studies · Gut microbiota and health · Ruminant Nutrition and Digestive Physiology
0000-0002-1136-4024
About
Dr Karl Fraser is a Principal Scientist working in Nutritional Metabolomics, and a member of the Food Chemistry and Informatics Team at the Bioeconomy Science Institute.
Dr Karl Fraser has worked on a diverse range of projects, ranging from those related to forage based agricultural systems i.e. forage, meat and milk metabolomics, to more recently biomarker discovery in the area of human health and nutrition. He has a wide range of experience in analytical chemistry and begun working in the area of metabolomics in 2005. He was the lead metabolomics researcher for the High-Value Nutrition National Science Challenge (2014-2024) and was involved in an array of projects ranging from phenotyping a 'functional gut disorder' cohort, to researching early biomarkers of type-2 diabetes in an Asian population, to the impacts (measured by metabolomics) of consuming New Zealand meat and milk products. He is currently involved in developing a 'systems nutrition' approach to understanding mechanisms of nutrition on human health and well-being. Key skills include analytical and metabolomic method development using both GC-MS and LC-MS instrumentation, and he has considerable experience with a wide range of mass spectrometer types, along with chromatography skills in UHPLC and GC. He is the first or co-author of over 130 peer-reviewed journal articles across a broad range of topics including animal metabolism, meat and milk flavour, endophyte alkaloid analysis, and metabolomic studies on plants, microbes and animal products.
He is a graduate of the University of Auckland, with a PhD in Chemistry and also an Associate Investigator of the Riddet Institute (2017-Now).
Employment
Employment history is unavailable.
Education
- 2010 - 2013
Projects & Funding
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Milk exosomes to enhance early-life development Ministry of Business, Innovation and Employment2018 - 2021
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Milks Mean More: Unlocking the potential of New Zealand's ruminant milks Ministry of Business, Innovation and Employment2018 - 2023
Publications (128)
- Integrated multi-omic and symptom clustering reveals lower-gastrointestinal disorders of gut-brain interaction heterogeneity Save
- A liquid chromatography-mass spectrometry-based method for the quantification of tutin in Coriaria arborea and its application to a longitudinal study Save
- Normalization of Gastrointestinal Symptoms in Adults With Constipation With Daily Green Kiwifruit Consumption: Protocol for an Open-Label Intervention Study Save
- Impact of infant nutrition on gut and brain nitrogenous metabolomes: Comparison of human milk and infant formula feeding in the minipiglet model Save
- Site-Specific Trafficking of Lipid and Polar Metabolites in Adipose and Muscle Tissue Reveals the Impact of Bariatric Surgery-Induced Weight Loss: A 6-Month Follow-Up Study Save
- Investigating Multi-Omic Signatures of Ethnicity and Dysglycaemia in Asian Chinese and European Caucasian Adults: Cross-Sectional Analysis of the TOFI_Asia Study at 4-Year Follow-Up Save
- Impact of Mānuka Honey on Symptoms and Quality of Life in Individuals With Functional Dyspepsia: Protocol for a Feasibility Randomized Controlled Trial Save
- Characterisation of the Plasma and Faecal Metabolomes in Participants with Functional Gastrointestinal Disorders Save
- Study Protocol for a Randomized Controlled Trial Investigating the Effects of the Daily Consumption of Ruminant Milk on Digestive Comfort and Nutrition in Older Women: The YUMMI Study Save
- Impact of Mānuka Honey on Symptoms and Quality of Life in Individuals With Functional Dyspepsia: Protocol for a Feasibility Randomized Controlled Trial (Preprint) Save
- Nourishing the Infant Gut Microbiome to Support Immune Health: Protocol of SUN (Seeding Through Feeding) Randomized Controlled Trial Save
- A metabolomics analysis of interspecies and seasonal trends in ruminant milk: The molecular difference between bovine, caprine, and ovine milk Save
- Effects of Defatted Rice Bran–Fortified Bread on the Gut Microbiota Composition of Healthy Adults With Low Dietary Fiber Intake: Protocol for a Crossover Randomized Controlled Trial Save
- Utilising a Clinical Metabolomics LC-MS Study to Determine the Integrity of Biological Samples for Statistical Modelling after Long Term −80 °C Storage: A TOFI_Asia Sub-Study Save
- Effects of Defatted Rice Bran–Fortified Bread on the Gut Microbiota Composition of Healthy Adults With Low Dietary Fiber Intake: Protocol for a Crossover Randomized Controlled Trial (Preprint) Save
- Comparative lipidomics analysis of in vitro lipid digestion of sheep milk: Influence of homogenization and heat treatment Save
- Nourishing the Infant Gut Microbiome to Support Immune Health: Protocol of SUN (Seeding Through Feeding) Randomized Controlled Trial (Preprint) Save
- Effects of Daily Ingestion of Two SunGold Kiwifruit for 6 Weeks on Metabolic and Inflammatory Biomarkers: A Randomized, Cross-Over, Exploratory Intervention Study Save
- A Diet Enriched with Lacticaseibacillus rhamnosus HN001 and Milk Fat Globule Membrane Alters the Gut Microbiota and Decreases Amygdala GABA a Receptor Expression in Stress-Sensitive Rats Save
- pH-dependent sedimentation and protein interactions in ultra-high-temperature-treated sheep skim milk Save