Jack Burcher
Research areas: Medicine · Otorhinolaryngology · Head and Neck Cancer Studies · Medicinal Plant Research · Bioactive natural compounds
0000-0002-1288-200X
About
Jack Burcher is an internal medicine resident at University of Florida Shands Hospital (Gainesville, Florida). After receiving his associates degree from Daytona State College (Deland, Florida), he studied biomedical sciences at the University of Central Florida (Orlando, Florida) while minoring in health sciences. In his undergraduate schooling, Jack Burcher investigated the effects of point mutations on selenocysteine lyase and, in a separate project, determined the relationship between the incidence of pediatric appendectomy and climate. In present day, cancer prevention and treatment with phytocompounds are Jack Burcher’s key research interests. Jack Burcher has presented his research on the efficacy of plant-based compounds against oral cancer in multiple poster symposiums. Jack Burcher’s most recently published work, “Relationship between Tumor Mutational Burden, PD-L1, Patient Characteristics, and Response to Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma” appeared in Cancers (Basel). This retrospective study sought to determine the connection between biomarkers and patient demographics, outcome, and response to PD-1 inhibitors. Although no association between PD-L1 expression and prognosis was found, tumor mutational burden was discovered to be correlated with progression-free survival and may be useful as a prognostic variable and predictor of response to immunotherapy.
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Publications (9)
- Dietary plants for oral cancer prevention and therapy: A review of preclinical and clinical studies Save
- Naringin–Dextrin Nanocomposite Abates Diethylnitrosamine/Acetylaminofluorene-Induced Lung Carcinogenesis by Modulating Oxidative Stress, Inflammation, Apoptosis, and Cell Proliferation Save
- Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds Save
- Potential of Synthetic and Natural Compounds as Novel Histone Deacetylase Inhibitors for the Treatment of Hematological Malignancies Save
- Bioactive phytocompounds for oral cancer prevention and treatment: A comprehensive and critical evaluation Save
- Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells Save
- A Review of the Role of Oral Microbiome in the Development, Detection, and Management of Head and Neck Squamous Cell Cancers Save
- Role of TMB and PD-L1 as Prognostic Factors and Predictors of Response to Immunotherapy in Head and Neck Squamous Cell Cancer Save
- Relationship between Tumor Mutational Burden, PD-L1, Patient Characteristics, and Response to Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma Save