Reshma Srilakshmi Rudraraju

About

My Research focuses on anti-tubercular drug development targeting both active and latent phases of bacteria. I have been involved in each phase of drug discovery from target selection to lead optimization. My research projects involved compound design, organic synthesis, protein purification, enzyme activity assays, protein crystallization and structure determination.

Employment

• Rutgers University Newark Post doctoral researcher
  2021 - Present
• Karolinska Institutet Post doc
  2017 - 2020

Education

• Birla Institute of Technology and Science - Hyderabad Campus Doctorate
  2014 - 2017
• Birla Institute of Technology and Science - Hyderabad Campus Masters
  2012 - 2014
• GITAM University Bachelors
  2008 - 2012

Projects & Funding

Projects & funding information is unavailable.

Publications (20)

• Lead derivatization of ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate and 5-bromo-2-(thiophene-2-carboxamido) benzoic acid as FabG inhibitors targeting ESKAPE pathogens
  European Journal of Medicinal Chemistry 2022 DOI: 10.1016/j.ejmech.2021.113976
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• Mycobacterium tuberculosis KasA as a drug target: Structure-based inhibitor design
  Frontiers in Cellular and Infection Microbiology 2022 DOI: 10.3389/fcimb.2022.1008213
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• Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase
  Journal of the American Chemical Society 2021 DOI: 10.1021/jacs.0c10214
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• A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens
  Bioorganic & Medicinal Chemistry 2021 DOI: 10.1016/j.bmc.2020.115898
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• Synthesis, in vitro, and in vivo (Zebra fish) antitubercular activity of 7,8-dihydroquinolin-5(6H)-ylidenehydrazinecarbothioamides
  Bioorganic Chemistry 2020 DOI: 10.1016/j.bioorg.2020.103626
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• Synthesis and evaluation of 4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran] analogues against both active and dormant Mycobacterium tuberculosis
  Bioorganic & Medicinal Chemistry 2018 DOI: 10.1016/j.bmc.2017.12.044
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• Identification and development of benzoxazole derivatives as novel bacterial glutamate racemase inhibitors
  European Journal of Medicinal Chemistry 2018 DOI: 10.1016/j.ejmech.2017.12.088
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• Lead identification and optimization of bacterial glutamate racemase inhibitors
  Bioorganic & Medicinal Chemistry 2018 DOI: 10.1016/j.bmc.2017.11.031
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• A robust synthesis of functionalized 2 H -indazoles via solid state melt reaction (SSMR) and their anti-tubercular activity
  Bioorganic & Medicinal Chemistry Letters 2017 DOI: 10.1016/j.bmcl.2017.02.021
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• Synthesis and anti-mycobacterial activity of 4-(4-phenyl-1H-1,2,3-triazol-1-yl)salicylhydrazones: revitalizing an old drug
  Archives of Pharmacal Research 2017 DOI: 10.1007/s12272-016-0882-x
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