KB
Kristopher Bosse
Children's Hospital of Philadelphia, University of Pennsylvania, Bowdoin College
Research areas: Medicine · Oncology · Neuroblastoma Research and Treatments · CAR-T cell therapy research · Immunotherapy and Immune Responses
0000-0002-1424-2858
Employment
-
The Children's Hospital of Philadelphia Assistant Professor2019 - Present
Education
- 2005 - 2010
- 1998 - 2002
Projects & Funding
Projects & funding information is unavailable.
Publications (29)
- Target antigen-displaying extracellular vesicles boost CAR T cell efficacy in cell and mouse models of neuroblastoma Save
- A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma. Save
- CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma. Save
- Targeting GPC2 on Intraocular and CNS Metastatic Retinoblastomas with Local and Systemic Delivery of CAR T Cells. Save
- BARD1 germline variants induce haploinsufficiency and DNA repair defects in neuroblastoma. Save
- Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival. Save
- Targeting of intracellular oncoproteins with peptide-centric CARs. Save
- A MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN-amplified neuroblastoma. Save
- GPC2 antibody-drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies. Save
- Serial Profiling of Circulating Tumor DNA Identifies Dynamic Evolution of Clinically Actionable Genomic Alterations in High-Risk Neuroblastoma. Save
- Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors. Save
- Epigenetic state determines inflammatory sensing in neuroblastoma. Save
- GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity. Save
- Antibody-Drug Conjugate Efficacy in Neuroblastoma: Role of Payload, Resistance Mechanisms, Target Density, and Antibody Internalization. Save
- A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. Save
- LIN28B promotes neuroblastoma metastasis and regulates PDZ binding kinase. Save
- CAMKV Is a Candidate Immunotherapeutic Target in MYCN Amplified Neuroblastoma. Save
- Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma. Save
- Differential killing of CD56-expressing cells by drug-conjugated human antibodies targeting membrane-distal and membrane-proximal non-overlapping epitopes. Save
- Suspected posaconazole toxicity in a pediatric oncology patient. Save