Dr. Prabhash Nath Tripathi
Research areas: Neuroscience · Cellular and Molecular Neuroscience · Alzheimer's disease research and treatments · Cholinesterase and Neurodegenerative Diseases · Synthesis and biological activity
0000-0002-1558-4964
About
My research work encompasses to develop the potential inhibitors of AChE and Aβ-aggregation. The compounds were extensively screened through in vitro biochemical assays and in vivo models. In addition, I have employed relevant computational methods to validate my experimental findings, such as using Schrodinger software and analytical tools, such as UV-Vis, FTIR, NMR, etc. In the collaborative research space, I have also worked with other research scholars in my laboratory to discover hybrids ligands for treating Alzheimer’s disease. I have worked on several scaffolds like 1,3,4-oxadiazole, 2-pyridylpiperazine, N-benzylpiperidine & ferulic acid to identify “leads” with promising inhibitory activities against cholinesterases, β secretase-1, amyloid-β, and oxidative stress. The rationally designed compounds were synthesized and evaluated by several in vitro enzymes & cell based assays, in vivo preclinical studies, and ex vivo studies using rat brains. Apart from this, I am having 3 years of industrial experience (Indian pharmaceutical MNC) in handling synthesis of organic molecules such as carbohydrate-based molecules (Nucleosides and Nucleotides), Biological dyes (Fluorescent molecules). In addition, I have expertise in molecular docking and molecular dynamics simulation techniques using Schrödinger Maestro software. I also have experience in performing in vitro enzymes and cell-based assays, in vivo and ex vivo studies using mice or rats brains. I have also synthesized nucleoside from D-glucose. Given my contribution, I co-authored publication in the Organic letters (ACS). I have also actively published (26 peer reviewed articles SCI & SCOPUS) in high impact peer reviewed journals, such as Bioorg Chem, Bioorg Med Chem, Eur J Med Chem, ACS ChemNeuro., ProgNeurobiol, etc. covering the broad field of Medicinal Chemistry. In addition, I had trained undergraduate students with nascent research skills. Recently I have collaborated with University of Sharjah, UAE to developing anti AD and anticancer molecules.
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