Mohammad Kashif
Parul University, Jawaharlal Nehru University, Banaras Hindu University, Jamia Millia Islamia, Aligarh Muslim University
0000-0002-1606-2340
About
I have completed my Ph.D. in Bioinformatics. My area of research are Structure Based Drug Designing/Discovery (SBDD), Immunoinformatics based Vaccine Development, Machine Learning and NGS Data analysis. During my Ph.D. I used computational methods to explore novel drugs using comparative modeling, docking/virtual screening ligand libraries and MD simulation studies against Leishmania donovani. I applied in silico and in vitro methods to identify new inhibitor (Z220582104) against LdPPDK enzyme. Similarly, ML-240 drug was identified against APX enzyme of Leishmania which showed significant antileishmanial activity. Therapy with ML-240 against established L. donovani infection in experimental animals (BALB/c) showed significant reduction in parasite burden. Histopathological alterations were also observed using hematoxylin and eosin (H&E) staining. Microscopic observation of inflammatory infiltrates in the periportal areas of liver sections was also performed. As evidenced by my publications and presentations of work at national and international conferences, I have good problem-solving skills and can work as part of an interdisciplinary team and contribute significantly. I have expertise in establishing research plans and managing projects both individually and collaboratively. I've also guided several student's M.Sc/M.Tech dissertations.
Employment
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Parul University Assistant Professor (Bioinformatics)2025 - Present
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Jawaharlal Nehru University Research Associate (ICMR-RA)2022 - Present
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Jamia Millia Islamia Project Assistant in INSA Young Scientist Project entitled “Role of Small G-protein in Leishmania donovani infection”2014 - 2015
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Jamia Millia Islamia Researcher2013 - 2014
Education
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Banaras Hindu University Ph.D in Bioinformatics2015 - 2021
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Jamia Millia Islamia M.Sc Bioinformatics2011 - 2013
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Jamia Millia Islamia B.Sc Biosciences2008 - 2011
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Aligarh Muslim University Dental Hygiene (Paramedical Course)2006 - 2008
Projects & Funding
Projects & funding information is unavailable.
Publications (21)
- MHC Class II restricted epitope prediction, crypticity analysis and B cell epitope identification from the proteome of Leishmania donovani Save
- Identification of KRAS mutants (G12C, G12D, and G12V) inhibitors Save
- Development of potent inhibitors against KRAS, its mutant G12R, allosteric and Switch-I/Switch-II site Save
- In Silico Identification of Novel and Potent Inhibitors Against Mutant BRAF (V600E), MD Simulations, Free Energy Calculations, and Experimental Determination of Binding Affinity Save
- Gene expression profiling to uncover prognostic and therapeutic targets in colon cancer, combined with docking and dynamics studies to discover potent anticancer inhibitor Save
- Exploring chemical space, scaffold diversity, and activity landscape of spleen tyrosine kinase active inhibitors Save
- In silico prediction of CD8+ and CD4+ T cell epitopes in Leishmania major proteome: Using immunoinformatics Save
- Synthesis, crystal structure, Hirshfeld surface analysis, DFT investigation, and molecular docking, of novel organic dithiocarbamates obtained from Baylis-Hillman adducts/alcohols at room temperature Save
- Recent Advances in Chemotherapeutics for Leishmaniasis: Importance of the Cellular Biochemistry of the Parasite and Its Molecular Interaction with the Host Save
- Identification of potential novel inhibitors against glutamine synthetase enzyme of Leishmania major by using computational tools Save