Wen-Chang Chang

About

Research Interests
*Prostaglandins
*Anti-Inflammation
*Signal Transduction
*Molecular Pharmacology

Employment

• Taipei Medical University Chair Professor
  2011 - Present
• National Cheng Kung University Emeritus Distinguished Chair Professor
  2011 - Present
• Academia Sinica Academician
  2004 - Present

Education

• National Science Council Distinguished Research Award
  1988 - Present
• University of Tokyo Ph.D.
  1973 - 1976
• The University of Tokyo Master degree
  1971 - 1973
• Taipei Medical University Bachelor of Pharmacy degree
  1965 - 1969

Projects & Funding

Projects & funding information is unavailable.

Publications (249)

• Contribution of Prostaglandin E2‐Induced Neuronal Excitation to Drug Resistance in Glioblastoma Countered by a Novel Blood–Brain Barrier Crossing Celecoxib Derivative
  Advanced Science 2025 5 citations DOI: 10.1002/advs.202506336
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• USP24 upregulation stabilizes PKA-Cα to promote lipogenesis, inflammation, and fibrosis during MASH progression
  Journal of Biomedical Science 2025 4 citations DOI: 10.1186/s12929-025-01148-4
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• Specificity Protein 1 is essential for the limb trajectory of ephrin-mediated spinal motor axons
  2025 0 citations DOI: 10.7554/elife.105518.1
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• Overcoming the Blood–Brain Tumor Barrier with Docetaxel-Loaded Mesoporous Silica Nanoparticles for Treatment of Temozolomide-Resistant Glioblastoma
  ACS Applied Materials & Interfaces 2024 48 citations DOI: 10.1021/acsami.4c04289
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• Sumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function
  BMC Molecular and Cell Biology 2024 1 citation DOI: 10.1186/s12860-023-00498-x
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• RNA‐binding protein‐regulated fibronectin is essential for EGFR‐activated metastasis of head and neck squamous cell carcinoma
  The FASEB Journal 2023 2 citations DOI: 10.1096/fj.202300527r
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• The complex role of eicosanoids in the brain: Implications for brain tumor development and therapeutic opportunities
  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2023 11 citations DOI: 10.1016/j.bbcan.2023.188957
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• Oleic acid-induced metastasis of KRAS/p53-mutant colorectal cancer relies on concurrent KRAS activation and IL-8 expression bypassing EGFR activation
  Theranostics 2023 10 citations DOI: 10.7150/thno.85855
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• Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression
  Journal of Biomedical Science 2022 23 citations DOI: 10.1186/s12929-022-00787-1
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• Estradiol-mediated inhibition of DNMT1 decreases p53 expression to induce M2-macrophage polarization in lung cancer progression
  Oncogenesis 2022 36 citations DOI: 10.1038/s41389-022-00397-4
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