Dr SANKAR K. GUCHHAIT
National Institute of Pharmaceutical Education and Research, National Institute of Pharmaceutical Education and Research, Indian Association for the Cultivation of Science
0000-0002-1817-2172
About
Dr Sankar K. Guchhait is a Synthetic Organic Medicinal Chemist, working as a Professor in the Department of Medicinal Chemistry at National Institute of Pharmaceutical Education and Research (NIPER), Mohali, India. He is an Associate Editor of the Royal Society of Chemistry Medicinal Chemistry journal from February, 2024. Research focuses majorly on anti-cancer drug discovery with design, focused synthesis, lead identification, and medicinal chemistry strategies. He has 28 + years of research experience and 17 + years of teaching experience in the field with PhD from IACS, India and postdoctoral research in three universities in USA for a total of 4 years. Research outcomes have been recognised with awards from various scientific societies. Creative strategy and innovation towards development of new therapeutic molecules is the key aim in research group.
For more details, please visit www.skguchhait.com
Research Area : Synthetic Organic Medicinal Chemistry
Anticancer drug discovery: Design and synthesis of heterocyclic compounds as human DNA topoisomerase IIα inhibitors, Microtubule-dynamics inhibitors, DNA polymerases inhibitors, and their SAR studies
Antibacterial drug discovery: Design and synthesis of heterocyclic compounds as target-specific antibacterial agents
Natural product-inspired, Scaffold-hopping, and Choice-based change medicinal chemistry strategies
Creating new from clinical trial agents and drugs; Identification of target-specific unique pharmacophore motifs; Exploration of patentable bioactive chemotypes
Structural modulations linked to pharmacodynamics, drug-likeness and ADMET and PK-relevant physicochemical properties
Synthesis of biologically relevant heterocyclic and natural product-based compounds
Synthetic methodology development: Construction of heterocyclic molecular skeletons, Synthon based chemistry, C-H bond functionalization, Ylide chemistry, Green chemistry
Awards and Recognition:
Associate Editor, RSC Medicinal Chemistry Journal, from February, 2024
Chemical Research Society of India (CRSI) Bronze Medal - 2022
Indian Chemical Society - Professor D. Nasipuri Memorial Award - 2015
Programme (BioCARe), proposals submitted in the area of Compounds of Medicinal Utility
Selected for ppt-presentation-evaluation stage for DST-SwarnaJayanti Fellowship, Year-2013.
Work published in J. Med. Chem. 2011, 54, 5013-5030 was recognized as “highly cited article”
(The American Chemical Society appreciated with a certificate)
Work published in ACS Med. Chem. Lett., 2015, 6, 481-485 was highlighted by featuring it as a cover art image in one of the issues (April, 2015) of the ACS Med. Chem. Lett.
Work (J. Org. Chem. 2017, 82, 2745−2752) was introduced in Synfacts as a highlight article.
Senior Research Fellowship (CSIR), Govt. of India, 1998-2000
Junior Research Fellowship (CSIR), Govt. of India, 1996-1998
Qualified National Eligibility Test (NET), Council of Scientific and Industrial Research (CSIR) for
Lectureship and Fellowship, Govt. of India, 1995
Qualified Graduate Aptitude Test in Engineering (GATE) for Fellowship, Govt. of India, 1996
Employment
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National Institute of Pharmaceutical Education and Research Professor, Research and teaching2017 - Present
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National Institute of Pharmaceutical Education and Research Associate Professor2012 - 2017
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National Institute of Pharmaceutical Education and Research Assistant Professor2007 - 2012
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University of California Riverside Postdoctoral research fellow2005 - 2006
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University of Illinois at Chicago Postdoctoral research fellow2004 - 2005
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University of Tennessee Postdoctoral Research Fellow2002 - 2004
Education
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Indian Association for the Cultivation of Science PhD1996 - 2001
Projects & Funding
Projects & funding information is unavailable.
Publications (80)
- Cyclopropyl-1,1-Dinitrile as a Five-Atom Synthon: Regioselective Ring-Opening and a Keteneimine–Enamine-Based Nitrile-to-Nitrile Condensation Affording an Entry to Pyridines Save
- Synthesis of Benzofurans and Dihydrobenzofurans from Phenols: Diastereoselective Benzylic C–H and Phenolic Site Annulation with Nsp3-ylides Save
- Scaffold‐Hopping of Natural Alkaloid Rutaecarpine: Synthesis and Anticancer‐Apoptosis and Autophagy Effects of Indole‐Based Analogs Save
- Regioselective Spirocyclopropyl C–C Cleavage and Ketene–Imine-Triggered Skeletal Rearrangement for the Synthesis of α-Carboline Save
- How to spare gut microbiota from antibiotic effects? PK-PD based innovative strategies, target specificity, and molecule-to-medicinal properties Save
- Topoisomerase II-targeting anticancer clinical candidates and drugs: A critical analysis, unravelling molecular medicinal insights and promising research roadmap Save
- Nitrile‐Stabilized Quaternary Ammonium Ylide as an Arylcyanomethylene Transfer Agent: Diastereoselective Synthesis of Spiro‐Cyanocyclopropyl‐2‐Oxindoles Save
- Medicinal Chemistry Education: Molecular Level Understanding of All Medicinal Properties and Innovative Strategies Save
- Rutaecarpine-inspired scaffold-hopping strategy and Ullmann cross-coupling based synthetic approach: Identification of pyridopyrimidinone-indole based novel anticancer chemotypes Save
- Natural‐Product‐Inspired Discovery of Trimethoxyphenyl‐1,2,4‐triazolosulfonamides as Potent Tubulin Polymerization Inhibitors Save