RL
Rui João Loureiro
International Institute of Molecular and Cell Biology, University of Coimbra, University of Lisbon, University of Aveiro, Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Protein Structure and Dynamics · Prion Diseases and Protein Misfolding · Alzheimer's disease research and treatments
0000-0002-1957-1853
Employment
- 2023 - Present
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University of Coimbra Junior Researcher2020 - 2023
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Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas PhD student2015 - 2019
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Instituto de Neurociencias de Alicante Research trainee2013 - 2014
Education
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Universidade de Lisboa PhD in Systems Biology2015 - 2019
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University of Aveiro MSc in Molecular Biomedicine2010 - 2012
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University of Aveiro BSc Degree in Biomedical Sciences - Minor in Molecular Biomedicine2007 - 2010
Projects & Funding
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Unraveling the influence of posttranscriptional modifications on RNA 3D structure formation and its dynamics, with the integrated use of theoretical and experimental approaches National Science Centre2025 - Present
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INCYPROnext: A key technology to enable the broad application of proteins in diagnostics and therapeutics. European Innovation Council2023 - 2024
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Leads4FLU – Novel antiviral against Influenza: NS1 target validation and lead discovery Universidade de Coimbra2020 - 2023
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The aggregation mechanism of β2-microglobulin in amyloid disease investigated through molecular simulations Fundação para a Ciência e a Tecnologia2015 - 2018
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Biosystems & Integrative Sciences Institute Fundação para a Ciência e a Tecnologia2015 - 2019
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Patterns of MNB/DYRK1A substrate recognition European Commission Leonardo da Vinci Program Agência Nacional Proalv2013 - 2014
Publications (25)
- Modeling flexible RNA 3D structures and RNA-protein complexes Save
- Folding Kinetics and Volume Variation of the ß-Hairpin Peptide Chignolin upon Ultrafast pH-Jumps Save
- Increasing the polarity of ß-lapachone does not affect its binding capacity with bovine plasma protein Save
- Interaction between a water-soluble anionic porphyrin and human serum albumin unexpectedly stimulates the aggregation of the photosensitizer at the surface of the albumin Save
- Interaction of Two Commercial Azobenzene Food Dyes, Amaranth and New Coccine, with Human Serum Albumin: Biophysical Characterization Save
- Unveiling New Druggable Pockets in Influenza Non-Structural Protein 1: NS1–Host Interactions as Antiviral Targets for Flu Save
- (One) microsecond dynamics and volume expansion in a single turn of Β-hairpin peptide chignolin upon ultra-fast pH-jump Save
- Biophysical characterization of the interaction between human serum albumin and two commercial azo food dyes Save
- Non-structural protein 1 (NS1) as a drug target for seasonal and pandemic Influenza Save
- Non-structural protein 1 (NS1) interaction with TRIM25 as a target for influenza antiviral therapy Save
- Non-structural protein 1 (NS1) interaction with PI3K as a target for influenza antiviral therapy Save
- Predicting stable binding modes from simulated dimers of the D76N mutant of β2-microglobulin Save
- The Early Phase of β2-Microglobulin Aggregation: Perspectives From Molecular Simulations. Save
- The early phase of the β2m aggregation mechanism: an integrative computational analysis based on the D76N mutant and ΔN6 variant Save
- Disclosing the aggregation mechanism of ß2-microglobulin in amyloid disease Save
- The Early Phase of β2m Aggregation: An Integrative Computational Study Framed on the D76N Mutant and the ΔN6 Variant Save
- The dimerization phase of the β2m aggregation mechanism: An integrative computational analysis based on the D76N mutant and ΔN6 variant Save
- The importance of unstructured termini in the aggregation cascade of beta-2-microglobulin: insights from molecular simulations of D76N mutant Save
- A tale of two tails: The importance of unstructured termini in the aggregation pathway of β2-microglobulin. Save
- The importance of unstructured termini in the aggregation cascade of beta-2-microglobulin: insights from molecular simulations of D76N mutant Save