GP
Gurubasavaraja Swamy Purawarga Matada
Research areas: Chemistry · Organic Chemistry · Synthesis and biological activity · Synthesis and Characterization of Heterocyclic Compounds · Computational Drug Discovery Methods
0000-0002-1978-6029
Employment
Employment history is unavailable.
Education
Education history is unavailable.
Projects & Funding
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Design and synthesis of novel fourth generation EGFR inhibitors selectively targeting triple mutant L85R/T790M/C797S mutation for Non-Small Cell Lung Cancer: A mitochondria target imaging and photodynamic approach Indian Council of Medical Research2021 - 2024
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Design, Insilico studies and synthesis of novel human epidermal growth factor receptor 2 (HER2) inhibitors as Anticancer agents Rajiv Gandhi University of Health Sciences2018 - 2021
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Design, synthesis and insilico studies of novel human epidermal growth factor receptor 2 (HER2) inhibitors as Anticancer agents Indian Council of Medical Research2018 - 2022
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Discovery of Pyrimidines and intermediates as a Human epidermal growth factor receptor (HER-2) and Apurinic/Apyrimidinic Endonuclease-1 (APE-1) inhibitors for breast cancer therapy: An synthetic approach DST-SERB2017 - 2021
Publications (66)
- Fused tricyclic aromatic and heteroaromatic scaffolds as anticancer agents: Recent advances in medicinal chemistry, structure–activity relationships, and therapeutic potential Save
- Pyrimidine-based HER2 inhibitors: Design, synthesis, biological evaluation, and molecular modeling for breast cancer therapy Save
- Rational Design, Synthesis, Biological Evaluation, and In Silico Study of N‐Cinnamamide/Benzamide‐(4‐(Substituted Phenyl)‐6‐(4‐Cyclohexylphenyl)pyrimidin‐2‐yl) Derivatives as EGFR Inhibitors Targeting EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S in NSCLC Save
- Design, Synthesis, and Molecular Docking Studies of Coumarin-chalcone Conjugates as Selective TNF-α and Weak COX-2 Inhibitors with Efficacy as an Antioxidant Save
- Pyrimidine derivatives as anticancer agents targeting kinases: design strategies, biological evaluation, and structure–activity relationship insights Save
- Design, Synthesis, and Mechanistic Studies of 5‐Substituted 2‐Oxindoles as Anticancer Agents Save
- Medicinal chemistry perspective of chalcone derivatives as anticancer agents: synthetic strategy, biological activity, and structure-activity relationship Save
- Medicinal chemistry perspective on quinazoline derivatives: Sustainable synthetic routes, anticancer evaluation, and SAR analysis Save
- Steroidal Scaffolds as Anticancer Agents: Evolution, FDA Approvals, Synthetic Derivatives, SAR Profiles, and Translational Perspectives Save
- Multistage Computational Evaluation of Bedaquiline Pyridyl Derivatives: Unveiling Anti‐Tubercular Potential Through QSAR, Molecular Docking, Molecular Dynamics, ADMET, and DFT Analysis Save
- Explanatory review on DDR inhibitors: their biological activity, synthetic route, and structure–activity relationship Save
- BRAF inhibitors in Melanoma: Structural Insights, Therapeutic Resistance, and Biological Evaluation of Quinazoline Derivatives Save
- Integrated Computational and Experimental Insights Into MEK1/2 Inhibitors: Structural Validation, Docking, ADMET, Molecular Dynamics, and Anticancer Evaluation Save
- Expanding the potential of pyridine scaffold for targeted therapy of cancer: Biological activity, molecular insights, and structure-activity relationship Save
- Exploring Thiazolidine-2,4‑dione derivatives as privileged scaffolds for targeted anticancer agents: Biological activity and structure-activity relationship (SAR) insights Save
- Exploring the molecular insights of imidazole and benzimidazole scaffold for cancer therapy: Synthesis, in-vitro cytotoxicity and SAR studies Save
- An outlook of docking analysis and structure-activity relationship of pyrimidine-based analogues as EGFR inhibitors against non-small cell lung cancer (NSCLC) Save
- Benzothiazole a privileged scaffold for Cutting-Edges anticancer agents: Exploring drug design, structure-activity relationship, and docking studies Save
- Medicinal chemistry perspective of JAK inhibitors: synthesis, biological profile, selectivity, and structure activity relationship Save
- Comprehensive Analysis of Antidiabetic Properties in Raphanus sativus Leaves: A Synergistic In-Silico and In-Vitro Approach Save