GC
Georgina Cornish
AstraZeneca PLC, AstraZeneca UK Ltd, Cancer Research UK, London Research Institute, QIMR Berghofer Medical Research Institute, The Francis Crick Institute, The University of Queensland
Research areas: Immunology and Microbiology · Immunology · T-cell and B-cell Immunology · Immunotherapy and Immune Responses · CAR-T cell therapy research
0000-0002-1984-6677
Employment
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AstraZeneca PLC Project Toxicologist- Cell Therapy Safety2023 - Present
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AstraZeneca UK Limited Associate Director2021 - 2023
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AstraZeneca UK Ltd Associate Principle Scientist2020 - Present
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The Francis Crick Institute Project Research Scientist2018 - Present
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Leucid Bio Ltd Senior Scientist2017 - 2018
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King's College London Research Associate2012 - 2017
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Imperial College London MRC Research Associate2010 - 2012
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National Institute for Medical Research (NIMR) MRC Career Development Fellow2005 - 2009
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London Research Institute PhD candidature2001 - 2005
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Imperial College Ludwig Institute for Cancer Research2000 - 2001
Education
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Cancer Research UK, London Research Institute PhD2001 - 2005
- 1999 - 1999
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University of Queensland BSc. Hons1996 - 1999
Projects & Funding
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Validation of non-invasive imaging with 68Ga-THP-RGD3 to detect rheumatoid arthritis in multiple joints simultaneously. Rosetrees Trust2017 - 2019
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Superresolution imaging of LFA-1 clustering in migrating T-cells HHMI Janelia Farm Advanced Imaging Centre2016 - 2016
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Functional genomic studies of PTPN22 in mouse models of arthritis Arthritis Research UK Arthritis Research UK2014 - 2019
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Differential signalling between IL-2 and IL-15 in CD8+ T-cells Biochemical Society2009 - 2009
Publications (26)
- Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS‐CoV‐2 spike protein Save
- Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases Save
- Adaptive immunity to SARS-CoV-2 in cancer patients: The CAPTURE study Save
- Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Save
- SARS-CoV-2 virus and antibodies in front-line Health Care Workers in an acute hospital in London: preliminary results from a longitudinal study Save
- Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans Save
- Default polyfunctional T helper 1 response to ample signal 1 alone. Save
- A subset of CCL25-Induced gut-homing T-cells affects intestial immunity to infection and cancer Save
- Differential nanoscale organisation of LFA-1 modulates T-cell migration Save
- Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice Save
- Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses Save
- The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens Save
- Enhancing PET Signal at Target Tissue in Vivo: Dendritic and Multimeric Tris(hydroxypyridinone) Conjugates for Molecular Imaging of α<inf>v</inf>β<inf>3</inf> Integrin Expression with Gallium-68 Save
- Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells Save
- Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity Save
- Protein clustering and spatial organization in T-cells Save
- NF-κB signaling mediates homeostatic maturation of new T cells Save
- Primed T cell responses to chemokines are regulated by the immunoglobulin-like molecule CD31 Save
- Tissue specific deletion of inhibitor of kappa B kinase 2 with OX40-cre reveals the unanticipated expression from the ox40 locus in skin epidermis Save
- Evidence of STAT5-dependent and -independent routes to CD8 memory formation and a preferential role for IL-7 over IL-15 in STAT5 activation Save