VV

Vinesh Vinayachandran

St. Jude Children's Research Hospital, Case Western Reserve University, Center for Cellular and molecular Biology, Johns Hopkins University

ORCID iD 0000-0002-2045-6086
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About

I am a scientist at St. Jude Children’s Research Hospital, contributing to groundbreaking pediatric cancer research through the Pediatric Cancer Dependency Accelerator (PedDep-II), with over 15 years of expertise in epigenomics. PedDep-II is a landmark collaboration uniting St. Jude, the Broad Institute MIT Harvard, and the Dana-Farber Cancer Institute. This joint effort aims to advance our understanding of pediatric cancers, uncover novel therapeutic targets, and develop innovative treatments to accelerate cures globally. Leveraging my deep expertise in epigenomics, data interpretation, molecular and computational biology, and Biochemistry, I collaborate with multidisciplinary teams to address critical gaps in pediatric oncology.
My work has elucidated (a) the fundamental determinants of nucleosome positioning, (b) the specificity and directionality of chromatin remodelers, (c) and transcriptional dynamics under stress conditions. My studies on transcriptional regulators (d) like KLF2 and KLF15 have highlighted their roles in lipid metabolism and inflammation, paving the way for potential therapies targeting obesity and metabolic diseases. Furthermore, my research in (e) environmental epigenetics demonstrates the reversible nature of epigenetic damage caused by pollution, offering hope for intervention strategies in metabolic syndromes.

Employment

  • St. Jude Children's Research Hospital Scientist
    2023 - Present
  • Case Western Reserve University Assistant Professor
    2019 - Present
  • Johns Hopkins University Research Scientist
    2017 - 2019
  • Pennsylvania State University Post doc/ Research Associate
    2011 - 2017

Education

  • Center for Cellular and molecular Biology PhD
    2006 - 2012

Projects & Funding

Projects & funding information is unavailable.

Publications (30)