Raelene Pickering

Employment

• Monash University Research Fellow
  2017 - Present

Education

Education history is unavailable.

Projects & Funding

• Treating lung disease with inhaled antisense RNA oligonucleotides Moderna Therapeutics (United States)
  2024 - 2027
• Pre-clinical testing of novel inhaled RNA therapies for stability, safety and effectiveness against SARS-CoV-2 to demonstrate proof of concept Medical Research Future Fund (MRFF)
• Preventing diabetic complications using anti-inflammatory peptides National Health and Medical Research Council
• SPLICE-SWITCHING OLIGONUCLEOTIDES FOR THE TREATMENT OF CHRONIC KIDNEY DISEASE National Health and Medical Research Council
• Splice switching oligonucleotides for the treatment of chronic kidney disease National Health and Medical Research Council

Publications (36)

• Melanocortins and Their Potential for the Treatment, Prevention and Amelioration of Complications of Diabetes
  Diabetology 2024 DOI: 10.3390/diabetology5010006
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• Pyridoxamine prevents increased atherosclerosis by intermittent methylglyoxal spikes in the aortic arches of ApoE-/- mice
  Biomedicine and Pharmacotherapy 2023 DOI: 10.1016/j.biopha.2022.114211
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• SARS-CoV-2 mouse adaptation selects virulence mutations that cause TNF-driven age-dependent severe disease with human correlates
  Proceedings of the National Academy of Sciences of the United States of America 2023 DOI: 10.1073/pnas.2301689120
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• Circulating Soluble ACE2 Plays an Independent Role to Protect against Vascular Damage in Diabetic Mice
  Antioxidants 2022 DOI: 10.3390/antiox11050987
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• Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice
  Proceedings of the National Academy of Sciences of the United States of America 2021 DOI: 10.1073/pnas.2101918118
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• Oxidative stress and inflammation in cardiovascular diseases
  Antioxidants 2021 DOI: 10.3390/antiox10020171
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• Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis
  Circulation Research 2020 DOI: 10.1161/CIRCRESAHA.120.316653
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• Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis
  Journal of Clinical Investigation 2019 DOI: 10.1172/JCI99987
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• A novel synthetic small molecule DMFO targets Nrf2 in modulating proinflammatory/antioxidant mediators to ameliorate inflammation
  Geetha Mathew, Arpeeta Sharma, R. J. Pickering +8 more
  Free Radical Research 2018 DOI: 10.1080/10715762.2018.1533636
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• Lipoxins protect against inflammation in diabetes-associated atherosclerosis
  Diabetes 2018 DOI: 10.2337/db17-1317
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• Lipoxins regulate the early growth response-1 network and reverse diabetic kidney disease
  Journal of the American Society of Nephrology 2018 DOI: 10.1681/ASN.2017101112
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• RAGE deletion confers renoprotection by reducing responsiveness to transforming growth factor-β and increasing resistance to apoptosis
  Diabetes 2018 DOI: 10.2337/db17-0538
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• Recent novel approaches to limit oxidative stress and inflammation in diabetic complications
  Clinical and Translational Immunology 2018 DOI: 10.1002/cti2.1016
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• Relationship between plasma 8-OH-deoxyguanosine and cardiovascular disease and survival in type 2 diabetes mellitus: Results from the ADVANCE trial
  Journal of the American Heart Association 2018 DOI: 10.1161/JAHA.117.008226
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• Corrigendum to “Lack of glutathione peroxidase-1 facilitates a pro-inflammatory and activated vascular endothelium” [Vasc. Pharmacol. 79 (2016) 32–42](S1537189115002384)(10.1016/j.vph.2015.11.001)
  Vascular Pharmacology 2017 DOI: 10.1016/j.vph.2017.09.006
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• Protective effect of inflammasome activation by hydrogen peroxide in a mouse model of septic shock
  Critical Care Medicine 2017 DOI: 10.1097/CCM.0000000000002070
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• Protective effect of let-7 miRNA family in regulating inflammation in diabetes-associated atherosclerosis
  Diabetes 2017 DOI: 10.2337/db16-1405
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• The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy
  European Journal of Pharmacology 2017 DOI: 10.1016/j.ejphar.2017.04.026
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• Lack of glutathione peroxidase-1 facilitates a pro-inflammatory and activated vascular endothelium
  Vascular Pharmacology 2016 DOI: 10.1016/j.vph.2015.11.001
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• ACE2 deficiency shifts energy metabolism towards glucose utilization
  Metabolism: Clinical and Experimental 2015 DOI: 10.1016/j.metabol.2014.11.004
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