Deepro Bonnerjee

About

My work is towards developing a few complex genetic computational networks, that have increased input and output handling capabilities and respond through Boolean logic. In the biological arena increased input & output throws open a lot of space for cross talk. Based upon electronic engineering design principles, our synthetic genetic circuits operate maintaining orthogonality within its sensing or responding channels. They are regulated by external chemical inducers, regulatory transcription factors and translational control. The generation of these circuits has demanded designing and characterizing of several synthetic Promoters and Ribosome binding sites to achieve fine tuning of the transcriptional and translational regulatory machinery so as to result in a near digital response. Mathematical models being developed for the genetic networks and their experimental validations from the systems show good predictability.

Employment

• Saha Institute of Nuclear Physics PhD Student
  2016 - Present

Education

• Anna University, Chennai M. Tech
  2014 - 2016

Projects & Funding

Projects & funding information is unavailable.

Publications (2)

• Design, Fabrication, and Device Chemistry of a 3-Input-3-Output Synthetic Genetic Combinatorial Logic Circuit with a 3-Input AND Gate in a Single Bacterial Cell
  Deepro Bonnerjee, Sayak Mukhopadhyay, Sangram Bagh
  Bioconjugate Chemistry 2019 DOI: 10.1021/acs.bioconjchem.9b00517
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• A frame-shifted gene, which rescued its function by non-natural start codons and its application in constructing synthetic gene circuits
  Kathakali Sarkar, Sayak Mukhopadhyay, Deepro Bonnerjee

  +2 more

  • Rajkamal Srivastava
  • Sangram Bagh
  Journal of Biological Engineering 2019 DOI: 10.1186/s13036-019-0151-x
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