Annika Niehrs

Employment

• Karolinska Institute Post Doctoral Fellow
  2022 - Present
• Leibniz-Institut für Virologie Post Doctoral Fellow
  2020 - 2021
• Heinrich-Pette-Institut Leibniz-Institut für Experimentelle Virologie PhD Student
  2016 - 2019

Education

• Albert-Ludwigs-Universität Freiburg MSc
  2013 - 2015
• Albert-Ludwigs-Universität Freiburg BSc
  2010 - 2013

Projects & Funding

Projects & funding information is unavailable.

Publications (16)

• Hepatic flares, their immune signatures, and ALT variability after nucleos(t)ide analogue cessation in HBeAg-negative hepatitis B
  JHEP Reports 2026 DOI: 10.1016/j.jhepr.2026.101875
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• Transient Interferon-Driven Natural Killer Cell Activation in Acute Hepatitis C
  The Journal of Infectious Diseases 2026 DOI: 10.1093/infdis/jiaf654
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• Transient tissue residency and lymphatic egress define human CD56bright NK cell homeostasis
  Nature Immunology 2025 DOI: 10.1038/s41590-025-02290-9
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• NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells.
  Cell reports 2024 DOI: 10.1016/j.celrep.2024.114089
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• HLA-DPA1*02:01~B1*01:01 is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells.
  Gut 2024 DOI: 10.1136/gutjnl-2023-329524
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• Kupffer cell-like syncytia replenish resident macrophage function in the fibrotic liver.
  Science (New York, N.Y.) 2023 DOI: 10.1126/science.abq5202
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• HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis.
  Martin E. Baumdick, Annika Niehrs, Frauke C. Degenhardt +97 more
  Gastroenterology 2023 DOI: 10.1053/j.gastro.2023.06.034
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• The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56bright NK cells.
  Frontiers in immunology 2023 DOI: 10.3389/fimmu.2023.1117320
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• Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells
  The EMBO Reports 2022 DOI: 10.15252/embr.202154133
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• Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C.
  Sarah Vollmers, Annabelle Lobermeyer, Annika Niehrs

  +26 more

  • Pia Fittje
  • Daniela Indenbirken
  • Jacqueline Nakel
  • Sanamjeet Virdi
  • Sebastien Brias
  • +21 more
  Frontiers in immunology 2022 DOI: 10.3389/fimmu.2022.922252
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• HIV-1 Nef-mediated downregulation of CD155 results in viral restriction by KIR2DL5+ NK cells.
  PLoS pathogens 2022 DOI: 10.1371/journal.ppat.1010572
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• KIR3DS1 directs NK cell–mediated protection against human adenovirus infections
  Science Immunology 2021 DOI: 10.1126/sciimmunol.abe2942
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• Primary HIV-1 Strains Use Nef To Downmodulate HLA-E Surface Expression.
  Journal of virology 2019 DOI: 10.1128/jvi.00719-19
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• A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44
  Nature Immunology 2019 DOI: 10.1038/s41590-019-0448-4
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• CD49a Expression Identifies a Subset of Intrahepatic Macrophages in Humans.
  Frontiers in immunology 2019 DOI: 10.3389/fimmu.2019.01247
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• Kinetics of HIV-1 Latency Reversal Quantified on the Single-Cell Level Using a Novel Flow-Based Technique.
  Journal of virology 2016 DOI: 10.1128/jvi.01448-16
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