Pearly Shuyi Ng

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Publications (16)

• A Series of Pyrazolo-Quinazoline Amines Inhibits the Cytochrome bd Oxidase in Mycobacterium tuberculosis
  Journal of Medicinal Chemistry 2026 DOI: 10.1021/acs.jmedchem.5c01616
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• Discovery of IID432 for Chagas Disease: A Cyanotriazole Inhibitor of Trypanosoma cruzi Topoisomerase II Achieves Sterile Cure After Short-Term Treatment in a Chronic Infection Model
  Journal of Medicinal Chemistry 2026 DOI: 10.1021/acs.jmedchem.5c02459
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• Correction to “Discovery of an Orally Bioavailable Reversible Covalent SARS-CoV-2 Mpro Inhibitor with Pan-Coronavirus Activity”
  Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.5c03617
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• Discovery of an Orally Bioavailable Reversible Covalent SARS-CoV-2 Mpro Inhibitor with Pan-Coronavirus Activity
  Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.5c00581
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• Button-Push On-Demand Synthesis for Rapid Optimization of Antiviral Peptidomimetics
  Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.4c12834
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• Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections
  Science 2023 DOI: 10.1126/science.adh0614
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• Discovery of a Novel Mycobacterial F‐ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines
  Adam Hotra, Priya Ragunathan, Pearly Shuyi Ng +20 more
  Angewandte Chemie International Edition 2020 DOI: 10.1002/anie.202002546
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• Discovery of a Novel Mycobacterial F‐ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines
  Angewandte Chemie 2020 DOI: 10.1002/ange.202002546
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• 5,6-fused-bicyclic compounds and compositions for the treatment of parasitic diseases
  2020
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• Cyanotriazole compounds and uses thereof
  2019
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• Synthesis of hydroxylated pyrrolidines by allenic cyclisation
  Tetrahedron 2016 DOI: 10.1016/j.tet.2016.08.029
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• Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents
  European Journal of Medicinal Chemistry 2015 DOI: 10.1016/j.ejmech.2015.10.008
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• Direct inhibitors of InhA are active against Mycobacterium tuberculosis
  Science Translational Medicine 2015 DOI: 10.1126/scitranslmed.3010597
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• A synthesis of 2-epi-fagomine using gold(I)-catalysed allene cyclisation
  Tetrahedron Letters 2011 DOI: 10.1016/j.tetlet.2011.03.130
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• Co-ligand effects in the catalytic activity of Pd(II)–NHC complexes
  Journal of Organometallic Chemistry 2011 DOI: 10.1016/j.jorganchem.2010.08.017
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• Anagostic Interactions and Catalytic Activities of Sterically Bulky Benzannulated N-Heterocyclic Carbene Complexes of Nickel(II)
  Organometallics 2008 DOI: 10.1021/om800004j
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