Pushkar Malakar

About

My postdoctoral work at National Cancer Institute, NIH, USA, involves exploring Cancer metabolism, Polyploidy, and Chromosome Instability.
My postdoctoral research projects at the Department of Biochemistry and Molecular Biology, Hebrew University, Israel was focused on Alternative splicing, Cancer metabolism, Long Non-coding RNAs (lncRNAs), Signaling, and Diabetes. My postdoctoral research projects at the Department of Biochemistry and Molecular Biology, Hebrew University, Israel were focused on alternative splicing, cancer metabolism, long non-coding RNAs (lncRNAs), signaling, and diabetes. In one of my projects, we showed that insulin induces INSR exon 11 inclusion (INSR-B) in pancreatic beta cells through activation of the Ras-MAPK/ERK signaling pathway and up-regulation of the splicing factor SRSF1. In another project, we showed that the lncRNA MALAT1 is upregulated in Hepatocellular carcinoma (HCC) and acts as a proto-oncogene through induction of oncogenic splicing factor SRSF1, activation of Wnt, and mTOR signaling pathways. In the third project, we studied the role of MALAT1 in regulating cancer glucose metabolism.
I completed my Ph.D. thesis with Prof. K.V. Venkatesh's laboratory in the Department of Biosciences and Bioengineering, IITB, which involved the characterization of the burden on growth due to unnecessary gene expression in natural and synthetic constructs utilizing lac operon and GAL regulon.

Employment

• Ramakrishna Math and Ramakrishna Mission Assistant Professor
  2022 - Present
• GITAM University Assistant Professor
  2021 - 2022
• National Institutes of Health Postdoctoral Visiting Fellow
  2019 - 2021
• Hebrew University of Jerusalem Postdoctoral Student
  2013 - 2019
• Indian Institute of Science Ph.D. Student
  2006 - 2007

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (19)

• Long noncoding RNAs in insulin signaling: mechanisms, metabolic roles, and therapeutic prospects
  Diabetes Research and Clinical Practice 2026 0 citations DOI: 10.1016/j.diabres.2026.113320
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• Molecular determinants of Bortezomib sensitivity and resistance in multiple myeloma
  Cancer Treatment and Research Communications 2026 0 citations DOI: 10.1016/j.ctarc.2026.101303
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• Downregulation of mTORC1 Signaling is Associated with Increased Sensitivity to Protein Synthesis Perturbations in Multiple Myeloma
  ACS Omega 2026 0 citations DOI: 10.1021/acsomega.6c02288
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• The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations
  RNA Biology 2024 33 citations DOI: 10.1080/15476286.2023.2286099
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• The role of alternative splicing and splicing factors in diabetes: Current status and future perspectives
  WIREs RNA 2024 6 citations DOI: 10.1002/wrna.1831
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• Role of synthetic biology to build a sustainable vaccine industry
  2024 0 citations DOI: 10.1016/B978-0-443-15378-5.00020-6
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• Long Noncoding RNA MALAT1 Regulates Cancer Glucose Metabolism by Enhancing mTOR-Mediated Translation of TCF7L2.
  Cancer research 2019 206 citations DOI: 10.1158/0008-5472.can-18-1432
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• Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer.
  Oncotarget 2016 164 citations DOI: 10.18632/oncotarget.9622
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• Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival.
  Scientific reports 2016 76 citations DOI: 10.1038/srep31222
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• Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation.
  Cancer research 2016 331 citations DOI: 10.1158/0008-5472.can-16-1508
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