Logesh Radhakrishnan

About

I am a molecular biologist and microbiologist with research interests in infectious diseases, host–pathogen interactions, antimicrobial resistance, and structure-based drug discovery. My research focuses on understanding the molecular mechanisms underlying the pathogenesis of Mycobacterium tuberculosis and translating these insights into novel therapeutic strategies.
During my Ph.D., I investigated the Enhanced Intracellular Survival (Eis/Rv2416c) protein of M. tuberculosis, exploring its functional role in bacterial virulence, immunomodulation, and intracellular survival, while identifying potential small-molecule inhibitors through integrated computational and experimental approaches. My current research is centered on the structure-based design and development of selective inhibitors against New Delhi Metallo-β-lactamase-1 (NDM-1) to address the growing challenge of antimicrobial resistance.
My expertise encompasses molecular cloning, recombinant protein expression and purification, enzyme characterization, microbiological and immunological techniques, molecular docking, virtual screening, molecular dynamics simulations, and experimental validation of drug candidates. I am committed to integrating computational and laboratory-based approaches to identify and validate novel therapeutic targets against multidrug-resistant bacterial pathogens.
My long-term goal is to contribute to the development of innovative antimicrobial therapies by combining molecular microbiology, structural biology, and computational drug discovery to address global challenges posed by tuberculosis and antimicrobial resistance.

Employment

• B.S. Abdur Rahman Crescent Institute of Science & Technology Project Research Scientist I
  2024 - 2027

Education

• B.S. Abdur Rahman Crescent Institute of Science & Technology M,sc Microbiology
  2014 - 2016
• B.S. Abdur Rahman Crescent Institute of Science & Technology PhD in Life Science
  ? - 2024

Projects & Funding

Projects & funding information is unavailable.

Publications (8)

• Synthesis, Characterization, and Comparative Analysis of Zinc Oxide Nanoparticles using Calendula Officinalis Flower Extract and its Antibacterial Activity
  Letters in Applied NanoBioScience 2025
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• Atomic-level binding interaction analysis of Mycobacterium tuberculosis membrane protein Rv1085c with Toll-Like receptor 2 to investigate its role in immune response
  In Silico Pharmacology 2025 DOI: 10.1007/s40203-025-00388-4
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• Lipopolysaccharide Purified from Salmonella typhi Sensitizes Human Red Blood Cells at Hemagglutinin concentration, leading to complete Hemolysis upon the addition of Jacalin- a lectin from Jackfruit
  Exon 2025 DOI: 10.69936/en05y0025
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• Targeting Aminoglycoside Acetyltransferase Activity of Mycobacterium tuberculosis (H37Rv) Derived Eis (Enhanced Intracellular Survival) Protein with Quercetin
  The Protein Journal 2024 DOI: 10.1007/s10930-023-10165-x
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• In Silico and In Vitro Investigation of Phytochemicals Against Shrimp AHPND Syndrome Causing PirA/B Toxins of Vibrio parahaemolyticus
  Applied Biochemistry and Biotechnology 2023 DOI: 10.1007/s12010-023-04458-1
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• Green synthesis of silver nanoparticles from plant latex and their antibacterial and photocatalytic studies
  Environmental Technology 2022 DOI: 10.1080/09593330.2021.1914181
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• Designing of a Chimeric Vaccine Using EIS (Rv2416c) Protein Against Mycobacterium tuberculosis H37Rv: an Immunoinformatics Approach
  Applied Biochemistry and Biotechnology 2022 DOI: 10.1007/s12010-021-03760-0
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• One-pot green route synthesis of silver nanoparticles from jack fruit seeds and their antibacterial activities with escherichia coli and salmonella bacteria
  Biocatalysis and Agricultural Biotechnology 2019 DOI: 10.1016/j.bcab.2019.101241
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