Suman Mishra, PhD

About

I am a structural biologist interested in understanding different aspects of protein folding in pathology. Currently, I am a postdoctoral scientist working with Dr. Benjamin Ryskeldi-Falcon at MRC-Laboratory of Molecular Biology, where I am developing better in vitro models for amyloidogenic proteins in disease. I did my PhD from the Molecular Biophysics Unit at the Indian Institute of Science, Bangalore where I employed single-particle cryo-EM to investigate mechanistic aspects of several bacterial pore-forming toxins from the Staphylococcus and Vibrio genera in a lipid membrane environment.

Employment

• MRC Laboratory of Molecular Biology MRC Career Development Fellow
  2025 - Present

Education

• Indian Institute of Science Bangalore Master of Science- Research, MS(Res)
  2019 - 2024
• Indian Institute of Science Bangalore Doctor of Philosophy, PhD
  2019 - 2024
• D.Y. Patil University, Navi Mumbai Bachelor of Technology (B.Tech) in Biotechnology
  2015 - 2019

Projects & Funding

Projects & funding information is unavailable.

Publications (9)

• Membrane Curvature During Membrane Rupture and Formation of Pentagonal Pyramidal Superassemblies by a Pore‐Forming Toxin, Vibrio cholerae Cytolysin, Using Single Particle Cryo‐EM
  Proteins: Structure, Function, and Bioinformatics 2026 DOI: 10.1002/prot.70075
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• Membrane curvature during membrane rupture and formation of pentagonal pyramidal superassemblies by a pore-forming toxin, Vibrio cholerae Cytolysin, using single particle cryo-EM
  2025 DOI: 10.1101/2025.07.19.665663
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• Membrane Rupture and Lipid–Protein Interaction of γ-Hemolysin from Staphylococcus aureus Using Cryo-EM
  Cryo-Electron Microscopy in Structural Biology (CRC Press) 2024 DOI: 10.1201/9781003326106
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• Emerging Trends in Cryo-EM-based Structural Studies of Neuropathological Amyloids
  Journal of Molecular Biology 2023 DOI: 10.1016/j.jmb.2023.168361
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• Cryo-EM-based structural insights into supramolecular assemblies of γ-hemolysin from S. aureus reveal the pore formation mechanism
  Structure 2023 DOI: 10.1016/j.str.2023.03.009
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• Structural insights into thermostable direct hemolysin of Vibrio parahaemolyticus using single‐particle cryo‐EM
  Proteins: Structure, Function, and Bioinformatics 2023 DOI: 10.1002/prot.26416
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• Cryo-EM-based structural insights into supramolecular assemblies of γ-Hemolysin from Staphylococcus aureus reveal the pore formation mechanism
  2022 DOI: 10.1101/2022.09.14.507916
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• Single-particle cryo-EM reveals conformational variability of the oligomeric VCC β-barrel pore in a lipid bilayer
  Journal of Cell Biology 2021 DOI: 10.1083/jcb.202102035
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• Conformational flexibility and structural variability of SARS-CoV2 S protein
  Structure 2021 DOI: 10.1016/j.str.2021.04.006
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