Hardik Jardosh
Dalriada Drug Discovery, Pharma Medica Research (Canada), Sardar Patel University, FMC Corporation
0000-0002-2637-9333
About
I am a translational medicinal chemist with over 10 years of experience in small-molecule drug discovery and synthetic organic chemistry. My research focuses on translating innovative chemical concepts into therapeutic candidates by integrating medicinal chemistry, synthetic methodology, and multidisciplinary drug discovery strategies.
My expertise spans hit identification and lead optimization, structure–activity relationship (SAR) studies, complex heterocyclic synthesis, targeted protein degradation (PROTACs), covalent drug discovery, GPCR ligand discovery, stable isotope-labeled molecules, and medicinal chemistry approaches that support pharmacology and ADMET research. Throughout my career, I have collaborated closely with biologists, pharmacologists, computational chemists, analytical scientists, and external research partners to advance multidisciplinary drug discovery programs.
I have led and contributed to the design, synthesis, and optimization of novel therapeutic molecules across multiple discovery programs. In addition to my published research, a substantial portion of my scientific contributions has been made through proprietary pharmaceutical research that remains confidential because of commercial and intellectual property considerations.
Beyond research, I have led discovery chemistry projects, mentored scientists, contributed to patented innovations, and participated in scholarly peer review. My scientific work spans both publicly disseminated research and proprietary pharmaceutical research, bridging medicinal chemistry and therapeutic innovation.
My research interests include translational medicinal chemistry, therapeutic innovation, synthetic methodology, chemical biology, GPCR pharmacology, targeted protein degradation, and the discovery and optimization of novel small-molecule therapeutics.
Employment
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Dalriada Drug Discovery Manager2021 - Present
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Pharma Medica Research (Canada) Senior Research Scientist2015 - 2021
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FMC Corporation Officer-R&D2014 - 2015
Education
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Sardar Patel University Ph.D.2009 - 2014
Projects & Funding
Projects & funding information is unavailable.
Publications (11)
- H2s-releasing mesalamine analogs Save
- Antimicrobial and antioxidant evaluation of new quinolone based aurone analogs Save
- Library design, synthesis and biological exploration of novel 3,4'-bicarbostyril derivatives as potent antimicrobial, antitubercular and antimalarial agents Save
- PS-TBD triggered general protocol for the synthesis of 4H-chromene, pyrano[4,3-b]pyran and pyrano[3,2-c]chromene derivatives of 1H-pyrazole and their biological activities Save
- Zinc Triflate Promoted General Synthetic Protocol for the Facile Construction of Chromenes and Pyrimidines Bearing N-Allyl Quinolone Nucleus Save
- Design and synthesis of biquinolone-isoniazid hybrids as a new class of antitubercular and antimicrobial agents Save
- Microwave-assisted CAN-catalyzed solvent-free synthesis of N-allyl quinolone-based pyrano[4,3-b]chromene and benzopyrano[3,2-c]chromene derivatives and their antimicrobial activity Save
- Microwave-assisted synthesis of pyrido[1,2-a]benzimidazole derivatives of β-aryloxyquinoline and their antimicrobial and antituberculosis activities Save
- Microwave-induced CAN promoted atom-economic synthesis of 1H-benzo[b]xanthene and 4H-benzo[g]chromene derivatives of N-allyl quinolone and their antimicrobial activity Save
- One step synthesis of pyrido[1,2-a]benzimidazole derivatives of aryloxypyrazole and their antimicrobial evaluation Save