Ambudkar SV

About

Dr. Ambudkar obtained his Ph.D. from Madurai Kamaraj University, Madurai, India, and received his postdoctoral training in membrane bioenergetics at the University of Maryland. He continued his postdoctoral work on biochemistry of membrane transport proteins at the Johns Hopkins University School of Medicine. In July 1995, after 5 years as an assistant professor in the departments of medicine and physiology at Johns Hopkins, he joined the Laboratory of Cell Biology at the CCR, NCI. He serves as Deputy Chief of the Laboratory of Cell Biology and Chief of the Transport Biochemistry Section.

Employment

• Johns Hopkins School of Medicine Assistant Professor
  1989 - 1995

Education

• Madurai Kamaraj University School of Biological Sciences Ph.D.
  1974 - 1978

Projects & Funding

Projects & funding information is unavailable.

Publications (40)

• Attenuation of ABCG2-dependent drug efflux by befotertinib restores chemosensitivity in multidrug-resistant non-small cell lung cancer cells
  Biomedicine & Pharmacotherapy 2026 0 citations DOI: 10.1016/j.biopha.2026.119613
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• Functional implications of the conformational landscape of a multidrug transporter revealed by Zebrafish Abcb4 structures
  Nature Communications 2026 0 citations DOI: 10.1038/s41467-026-73751-4
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• Nanoengineered photosensitizers for photodynamic priming to overcome P‐glycoprotein‐mediated multidrug resistance
  Photochemistry and Photobiology 2026 1 citation DOI: 10.1111/php.70049
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• (N)-Methanocarba Adenosine Derivatives as Dual Modulators of P-Glycoprotein and ABCG2 Transporters
  Journal of Medicinal Chemistry 2026 0 citations DOI: 10.1021/acs.jmedchem.5c03705
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• BLU-945 suppresses ABCB1-mediated drug efflux and restores chemosensitivity in multidrug-resistant cancer cells
  European Journal of Pharmacology 2026 0 citations DOI: 10.1016/j.ejphar.2026.179220
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• Functional Implications of the Conformational Landscape of a Multidrug Transporter Revealed by Structures of Zebrafish Abcb4
  2025 0 citations DOI: 10.1101/2025.05.30.656806
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• Photodynamic priming modulates cellular ATP levels to overcome P‐glycoprotein‐mediated drug efflux in chemoresistant triple‐negative breast cancer
  Photochemistry and Photobiology 2025 9 citations DOI: 10.1111/php.13970
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• Mutational analysis reveals the importance of residues of the access tunnel inhibitor site to human P‐glycoprotein (ABCB1)‐mediated transport
  Protein Science 2024 7 citations DOI: 10.1002/pro.5155
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• ABCG2 Mediates Resistance to the Dual EGFR and PI3K Inhibitor MTX-211 in Cancer Cells
  International Journal of Molecular Sciences 2024 1 citation DOI: 10.3390/ijms25105160
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• Epidermal Growth Factor Receptor Inhibitor Mobocertinib Resensitizes Multidrug-Resistant Cancer Cells by Attenuating the Human ATP-Binding Cassette Subfamily B Member 1 and Subfamily G Member 2
  ACS Pharmacology & Translational Science 2024 7 citations DOI: 10.1021/acsptsci.3c00217
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