Niraj Harish Tolia
National Institutes of Health, Washington University in St. Louis, Watson School of Biological Sciences, Imperial College London, Washington University in St Louis
0000-0002-2689-1337
About
Dr. Tolia became the Chief of the Host-Pathogen Interactions and Structural Vaccinology section in the Laboratory of Malaria Immunology and Vaccinology in May 2018. He is a tenured Senior Investigator in the Division of Intramural Research, NIAID. He has pioneered the structural and biophysical studies of host-pathogen interactions, antibody neutralization and immunogen design for malaria. A major goal is to define how processes required for malaria parasite survival are mediated and can be exploited for preventative, therapeutic and diagnostic purposes. This work has direct implications for drug and vaccine development. His laboratory uses the tools of microbiology, cell biology, biochemistry, biophysics and structural biology to study proteins and complexes.
Dr. Tolia received his B.Sc. from Imperial College, and his Ph.D. from the Cold Spring Harbor Laboratory School of Biological Sciences as a Leslie Quick Jr. Fellow. He began his independent career as an Assistant Professor of Molecular Microbiology, and an Assistant Professor of Biochemistry and Molecular Biophysics at Washington University School of Medicine in November 2007. He was the recipient of an Investigator in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund and his research was supported by grants from the National Institutes of Health, the Edward Mallinckrodt, Jr. Foundation, the American Heart Association, the W.M. Keck Foundation and the Children’s Discovery Institute.
Employment
-
National Institutes of Health Senior Investigator2018 - Present
-
Washington University in St. Louis Associate Professor2015 - 2018
-
Washington University in St Louis Assistant Professor2007 - 2014
-
Cold Spring Harbor Laboratory Postdoctoral Fellow2004 - 2007
-
Pfizer Global Research and Development Sandwich Industrial Trainee1997 - 1998
Education
-
Watson School of Biological Sciences1999 - 2004
-
Imperial College London BSc1995 - 1999
Projects & Funding
Projects & funding information is unavailable.
Publications (93)
- Comprehensive characterization of Plasmodium vivax antigens using a high-density peptide array Save
- PvDBP gene amplification is associated with functional immune evasion by Plasmodium vivax in vivo Save
- Plasmodium falciparum exploits NUAK1 to establish infection in human erythrocytes Save
- CD44 cross-linking promotes Plasmodium falciparum invasion Save
- The tetracycline resistome is shaped by selection for specific resistance mechanisms by each antibiotic generation Save
- C10-Benzoate Esters of Anhydrotetracycline Inhibit Tetracycline Destructases and Recover Tetracycline Antibacterial Activity Save
- Covalent Irreversible Inhibitors of Tetracycline Destructases Save
- CD44 cross-linking promotes Plasmodium falciparum invasion Save
- RH5 antigenic landscape shapes vaccine and antibody development Save
- Multistage protective anti-CelTOS monoclonal antibodies with cross-species sterile protection against malaria. Save