Mani Shankar Babu

About

Research during my Ph.D. was focused in teasing out the mechanism of activation of NF-kappaB pathway even in the presence of its inhibitor IkappaB alpha in cervical adenocarcinoma of human uterine cervix. My post doctoral research was to identify the metabolic vulnerabilities of human melanoma cell lines to inhibition of glycolysis by phytochemicals or by mitochondrial metabolites that force the cells to perform oxidative phosphorylation which slows the cell proliferation.

Employment

Employment history is unavailable.

Education

• Indiana University School of Medicine Post Doctoral Research
  2016 - 2017
• Rajiv Gandhi Centre for Biotechnology Ph.D.
  2004 - 2011

Projects & Funding

Projects & funding information is unavailable.

Publications (6)

• Targeting K-Ras and apoptosis-driven cellular transformation in cancer
  Cell Death Discovery 2021 DOI: 10.1038/s41420-021-00457-5
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• Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
  PLoS ONE 2018 DOI: 10.1371/journal.pone.0191419
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• Quercetin attenuates Monocyte Chemoattractant Protein-1 gene expression in glucose primed aortic endothelial cells through NF-κB and AP-1
  Pharmacological Research 2010 DOI: 10.1016/j.phrs.2010.06.003
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• Biophysical evaluation of two red-shifted hypocrellin B derivatives as novel PDT agents
  Journal of Photochemistry and Photobiology B: Biology 2009 DOI: 10.1016/j.jphotobiol.2008.09.007
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• Genistein induces apoptosis in ovarian cancer cells via different molecular pathways depending on Breast Cancer Susceptibility gene-1 (BRCA1) status
  European Journal of Pharmacology 2008 DOI: 10.1016/j.ejphar.2008.04.041
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• Anti-inflammatory effect of curcumin involves downregulation of MMP-9 in blood mononuclear cells
  International Immunopharmacology 2007 DOI: 10.1016/j.intimp.2007.08.018
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