ML
Michelle Sue Jann Lee
Also known as: Michelle Lee Sue Jann
Institute of Medical Science, The University of Tokyo, Immunology Frontier Research Center, The University of Osaka, The University of Osaka, National University of Malaysia
Research areas: Immunology and Microbiology · Immunology · Malaria Research and Control · Immune Response and Inflammation · Immunotherapy and Immune Responses
0000-0002-2694-0549
Employment
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Institute of Medical Science, The University of Tokyo Assistant Professor2020 - 2024
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Immunology Frontier Research Center Assistant Professor2017 - 2020
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Immunology Frontier Research Center Research Assistant2015 - 2017
Education
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Osaka University PhD2013 - 2017
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National University of Malaysia Biochemistry2009 - 2012
Projects & Funding
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Mechanism of malaria-induced disruption of hematopoietic stem cell niche in the bone marrow The Japan Society for the Promotion of Science (JSPS)2022 - 2024
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B細胞におけるパターン認識受容体の活 性化を標的とした胚中心形成の可能性 の検討 Mochida Memorial Foundation for Medical and Pharmaceutical Research2022 - 2023
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Identifying the role of extracellular particles in B cell activation for germinal center formation JST- CREST Young Challenge Program2022 - 2024
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Investigation of the role of B-cell-intrinsic TBK1 for germinal center formation The Japanese Society of Immunology (JSI)2022 - 2023
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Chronic impact of malaria on bone marrow niches and immune regulation after recovery from infection The Japan Society for the Promotion of Science (JSPS)2020 - 2022
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Malarial parasite products cause chronic inflammatory bone loss The Japan Society for the Promotion of Science (JSPS)2018 - 2024
Publications (13)
- 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation Save
- Acute malaria suppresses the B lymphocytic niche in the bone marrow through the alteration of CXCL12-abundant reticular cells Save
- Anti-tumor immunity by transcriptional synergy between TLR9 and STING activation Save
- B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice Save
- Using a new three-dimensional CUBIC tissue-clearing method to examine the brain during experimental cerebral malaria Save
- TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation Save
- B cell-intrinsic MyD88 signaling controls IFN-γ-mediated early IgG2c class switching in mice in response to a particulate adjuvant Save
- Rapid Quantification of NETs In Vitro and in Whole Blood Samples by Imaging Flow Cytometry Save
- DAMP-inducing adjuvant and PAMP adjuvants parallelly enhance protective type-2 and type-1 immune responses to influenza split vaccination Save
- Tissue-specific immunopathology during malaria infection Save
- Unforeseen pathologies caused by malaria Save
- Plasmodium products persist in the bone marrow and promote chronic bone loss Save
- Current status of synthetic hemozoin adjuvant: A preliminary safety evaluation Save