YVAN TORRENTE
Ystem Srl, Stem Cell Interdepartmental Research Centre - Università degli Studi di Milano, Università degli Studi di Milano, Université Paris 7, Ospedale Maggiore Policlinico
About
Yvan Torrente received his degree in Medicine and Surgery at the University of Milan (1995). After his degree he carried out an intense research activity abroad, winning a PhD in muscular dystrophies at the Genetic Medicine Laboratory, University of Quebec – Canada, directed by Prof. J. P. Tremblay, in 1998 and applying for a Ph.D. in Biochemistry at the University of Paris in 2003. In 2002 he was appointed Director of Stem Cell Laboratory and achieved his specialization in Neurology thus becoming Neurologist at Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milan and Staff Neurologist at the Dino Ferrari Center. Since 2004 he has been Assistant Professor in Neurology and from 2016 he is Professor in Neurology at Università degli Studi di Milano, focusing on stem cells therapies for neuromuscular diseases with specific commitment to Duchenne Muscular Dystrophy. In 2002 he particularly stood out by coordinating the first Phase I clinical project for the validation of stem cell transplantation in dystrophic patients. He conducted other groundbreaking clinical trials using a combination of epithelial stem cells and scaffolds for nerve and sensor restoration after injuries (2009), a Phase I/II study concerning an allotransplantation of mesoangiblasts as treatment for DMD (2010), a stem cell autografting in patients affected by facioscapulohumeral muscular dystrophy (2011), a combined treatment of autologous stem cells and platelet gel in a spinal cord injured patient.
Lately, he has been adding to his consolidated expertise in neuromuscular dystrophies, stem cell and gene approaches, a specific focus upon inflammatory pathways and microbiota involvement in muscle disorders.
He has contributed to the foundation of the Stem Cell Interdepartmental Research Center - UNISTEM of the University of Milan (2006) and he is involved in several teaching courses for the Faculties of Medicine and Surgery and Biological and Molecular Sciences at the University of Milan. He has authored over 80 publications on international journals, 10 book chapters and holds a significant reviewer activity for prestigious scientific journals, including Molecular Therapy, Experimental Cell Research, The Journal of Molecular Medicine, The Journal of Biological Chemistry, The Journal of Clinical Investigation, FEBS Letters and The Journal of Cell Biology.
He was funder at Ystem S.r.l., a biotech company which started out its activity as a spin-off belonging to the University of Milan.
Employment
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Ystem Srl President and Scientific director2012 - Present
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Fondazione Filarete Director of the Stem Cell Platform2009 - 2012
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Stem Cell Interdepartmental Research Centre - Università degli Studi di Milano Co-founder2006 - Present
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Ospedale Maggiore Policlinico Neurologist2005 - Present
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Università degli Studi di Milano Assistant Professor of Neurology2005 - Present
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Associazione Centro Dino Ferrari Staff Neurologist2005 - Present
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Università degli Studi di Milano Instructor of Neurology2005 - Present
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Università degli Studi di Milano Director of the Stem Cell Laboratory2002 - Present
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Istituto Superiore di Sanita Co-author and Coordinator of “Progetto Uomo” – Phase I Clinical trial involving stem cell transplantation for dystrophic diseases2002 - 2002
Education
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Università degli Studi di Milano Assistant Professor of Neurology? - 2004
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Université Paris 7 Ph.D. in Biochemistry? - 2003
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Università degli Studi di Milano Specialist in Neurology? - 2002
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Unité de Recherche en Génetique Humaine - Pavillon CHUL/CHUQ Postdoctoral fellowship in Muscular Dystrophies? - 1998
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Università degli Studi di Milano M.D. degree cum laude? - 1995
Projects & Funding
Projects & funding information is unavailable.
Publications (94)
- EEG Power Analysis of an Emotionally Neutral VR Experience: What is Underneath? Save
- Brain-heart interactions in late-onset major depressive disorder revealed by multimodal HRV-driven fMRI Save
- Glioblastoma: Overview of Proteomic Investigations and Biobank Approaches for the Development of a Multidisciplinary Translational Network Save
- Exploring the Gut Microbiota–Muscle Axis in Duchenne Muscular Dystrophy Save
- Advancing Biomarker Discovery and Therapeutic Targets in Duchenne Muscular Dystrophy: A Comprehensive Review Save
- Combinatorial activation of the WNT‐dependent fibrogenic program by distinct complement subunits in dystrophic muscle Save
- Immunoproteasome Inhibition Ameliorates Aged Dystrophic Mouse Muscle Environment Save
- Inhibition of the immunoproteasome modulates innate immunity to ameliorate muscle pathology of dysferlin-deficient BlAJ mice Save
- Flavonoids and Omega3 Prevent Muscle and Cardiac Damage in Duchenne Muscular Dystrophy Animal Model Save
- The Immune System in Duchenne Muscular Dystrophy Pathogenesis Save