Alvaro Sanchez-Martinez

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Publications (25)

• Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes inC9orf72ALS/FTD models
  Life Science Alliance 2024 DOI: 10.26508/lsa.202402853
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• Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction inC9orf72ALS/FTDin vivomodels and patient iNeurons
  2023 DOI: 10.1101/2023.10.02.560439
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• FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo
  PLOS Biology 2023 DOI: 10.1371/journal.pbio.3002244
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• Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes inPink1/parkinmodels
  2023 DOI: 10.1101/2023.05.14.540700
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• A cell-penetrant peptide blocking C9ORF72 -repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins
  Lydia M. Castelli, Ya-Hui Lin, Álvaro Sánchez-Martínez +19 more
  Science Translational Medicine 2023 DOI: 10.1126/scitranslmed.abo3823
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• Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster
  eLife 2023 DOI: 10.7554/eLife.84424
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• Parkin drives pS65‐Ub turnover independently of canonical autophagy in Drosophila
  The EMBO Reports 2022 DOI: 10.15252/embr.202153552
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• DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion
  The EMBO Journal 2022 DOI: 10.15252/embj.2021109390
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• Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration.
  Neurobiology of disease 2019 DOI: 10.1016/j.nbd.2019.104678
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• Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila
  Nature Communications 2019 DOI: 10.1038/s41467-019-10857-y
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• Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo.
  Cell reports 2019 DOI: 10.1016/j.celrep.2019.04.033
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• Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction
  Sophia von Stockum, Álvaro Sánchez-Martínez, Samantha Corrà +14 more
  Life Science Alliance 2019 DOI: 10.26508/lsa.201900392
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• Characterization of Drosophila ATPsynC mutants as a new model of mitochondrial ATP synthase disorders
  PLOS ONE 2018 DOI: 10.1371/journal.pone.0201811
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• The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease.
  Cell reports 2018 DOI: 10.1016/j.celrep.2018.05.009
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• Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin
  Journal of Cell Biology 2018 DOI: 10.1083/jcb.201801044
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• Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss.
  Human molecular genetics 2018 DOI: 10.1093/hmg/ddy069
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• SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
  Nature Communications 2017 DOI: 10.1038/ncomms16063
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• Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models.
  2016 DOI: 10.1038/srep31380
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• Superoxide Dismutase (SOD)-mimetic M40403 Is Protective in Cell and Fly Models of Paraquat Toxicity: IMPLICATIONS FOR PARKINSON DISEASE.
  2016 DOI: 10.1074/jbc.m115.708057
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• The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy.
  2014 DOI: 10.1371/journal.pgen.1004815
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