Varsha Singh
University of Pennsylvania, Lund University, University of Delhi, National Institute of Immunology
Research areas: Medicine · Pulmonary and Respiratory Medicine · Lung Cancer Treatments and Mutations · Lung Cancer Diagnosis and Treatment · Cancer Genomics and Diagnostics
0000-0002-2761-7102
About
1. Currently working with single-cell genomics in blood cancers (childhood ALL and AML).
Skills Learning and Goal: Novel Primary Template-directed Amplification (PTA) technology in single-cell (DNA isolation from single-cells), Multiplex PCR (Targeted Sequencing), Cell Culture Work (For Flow Sample processing), Flow Cytometry (Single-Cell Sorting), Mouse handling (Bleeding, Dissection and tissue processing), Bioinformatics (Targeted and Whole Exome Sequencing data), R and Phyton language (Plotting graphs and data analysis).
2. I have worked on molecular and immunological aspects of lung cancer (NSCLC and SCLC).
Key Skills Acquired: Sequencing ( Whole Exome, Targeted and Sanger), PCR ( Digital Droplet, Real-Time, Reverse Transcriptase and Conventional), Pathological Characterization, NanoString technology, Staining and writing research papers
3. I have worked on human neurodegenerative tauopathies in the Drosophila disease model.
Key Skills Acquired: Confocal Microscopy, Immunostaining and Histopathology, Drosophila handling
Employment
- 2024 - Present
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Lund University Post-Doctoral Fellow2021 - 2024
Education
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University of Delhi MPhil (Biotechnology)2013 - 2015
- 2010 - 2012
- 2007 - 2010
Projects & Funding
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Unravelling clonal diversity in infant KMT2A-R acute leukemia and its pathogenetic impact Barncancerfonden Childhood Cancer Research 20222022 - Present
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Topic 1: Whole Exome Sequencing (WES) in Non-Small Cell Lung Carcinoma (NSCLC): Identification of Novel Biomarkers Topic 2: Liquid Biopsy in the Detection of EGFR Activating and Resistance Mutations in Advanced Pulmonary Adenocarcinoma. Department of Science (DST)2019 - 2019
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Survival analysis of common and uncommon EGFR (Epidermal Growth Factor Receptor) mutations in non-small cell lung carcinoma Indian Society for Study of Lung Cancer (NALCCON 2019)2019 - 2019
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MAP kinase signaling pathway in pulmonary adenocarcinomas: A study from India Council of Scientific and Industrial Research (CSIR)2018 - 2018
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EGFR downstream signaling pathways and Other Oncogenic Drivers in Non–Small Cell Lung Carcinoma (NSCLC). Council of Scientific and Industrial Research, India2016 - 2020
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EGFR downstream signaling pathways and Other Oncogenic Drivers in Non–Small Cell Lung Carcinoma (NSCLC). All-India Institute of Medical Sciences2015 - 2015
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Screening and characterization of a novel genetic modifier of human neurodegenerative tauopathies in Drosophila disease model University Grants Commission-Delhi University2013 - 2014
Publications (27)
- SupeRJump: Determining normal and leukemic differentiation fate through semi-supervised jump diffusion modeling Save
- Genotype-immunophenotype relationships in NPM1-mutated AML clonal evolution uncovered by single-cell multiomic analysis Save
- The genomic landscape of relapsed infant and childhood KMT2A-rearranged acute leukemia Save
- A phase II study of metformin plus pemetrexed and carboplatin in patients with non-squamous non-small cell lung cancer (METALUNG) Save
- The Rise and Fall of Leukemia Clones in Longitudinal Samples from Diagnosis to Relapse in KMT2A-rearranged Infant and Childhood Leukemia Save
- IDH1/2 Mutations in Sinonasal Undifferentiated Carcinomas Previously Undescribed IDH2 R172K and R140x Variants Save
- Identification of Molecular Biomarkers Associated with Non-Small-Cell Lung Carcinoma (NSCLC) Using Whole-Exome Sequencing Analysis Save
- EGFR mutation testing on plasma and urine samples: A pilot study evaluating the value of liquid biopsy in lung cancer diagnosis and management Save
- GTF2I Mutation in Thymomas: Independence From Racial-Ethnic Backgrounds. An Indian/German Comparative Study Save
- Correlation of TTF-1 immunoexpression and EGFR mutation spectrum in non–small cell lung carcinoma Save
- EGFR mutation testing in cytology smears of advanced non‐small cell lung carcinomas: Practical applications in low‐resource laboratories Save
- SMARCA4/BRG1–Deficient Non–Small Cell Lung Carcinomas: A Case Series and Review of the Literature Save
- Spectrum of uncommon and compound epidermal growth factor receptor mutations in non-small-cell lung carcinomas with treatment response and outcome analysis: A study from India Save
- Epidermal growth factor receptor mutation status in pulmonary adenocarcinoma: Multi-institutional data discussion at national conference of “Lung Cancer Management in Indian context” Save
- Molecular Pathology of Thymic Epithelial Tumors Save
- Spindle epithelial tumour with thymus‐like elements presenting with lymph node metastasis: An illustrative case report with review of literature Save
- EP1.01-22 Liquid Biopsy in the Detection of EGFR Activating and Resistance Mutations in Advanced Pulmonary Adenocarcinoma Save
- Epidermal growth factor receptor (EGFR), KRAS, and BRAF mutations in lung adenocarcinomas: A study from India Save
- P1.14-48 Whole Exome Sequencing (WES) in Non-Small Cell Lung Carcinoma (NSCLC): Identification of Novel Biomarkers Save
- P2.09-06 Epidermal Growth Factor Receptor (EGFR) Mutation Spectrum in Pulmonary Adenocarcinomas: Indian Experience Save