Premlata Kumari
Sardar Vallabhbhai National Institute of Technology, University of Allahabad
0000-0002-2833-3646
About
Major research areas include the design and manufacture of bioactive drug candidates as well as their in vitro and in silico analyses. Designing more potent drug candidates is also made possible by the examination of the structure-activity relationship, which is also her area of research interest. The identification and quantification of chemical markers using the UHPLC and HPLC procedures aid in assessing the product's quality. The research team is also actively engaged in phytochemical extraction and their use in a wide range of sectors. The research team recently developed an industrial one-pot method for making the crucial intermediate, 1-Acetyl-4-(4-hydroxyphenyl)piperazine (AHPP) for antifungal drug, ketoconazole. This procedure has already been submitted for patenting processing.Already have two process patents granted, 1. One pot cost effective industrial preparation of chlorzoxazone, which is used to relax certain of our body's muscles and ease the pain brought on by acute (short-term) painful muscle or bone problems and 2. A process for preparation of Dibenzothiazepinone is a crucial raw material for the industrial production of Quetiapine fumarate, an antipsychotic drug. In addition, Dr. Kumari has edited a book titled "Strategies towards the Synthesis of Heterocycles and Their Applications," with publisher, Intechopen Limited.
Employment
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Sardar Vallabhbhai National Institute of Technology Associate Professor2006 - Present
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Sardar Vallabhbhai National Institute of Technology Associate Professor2006 - Present
Education
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University of Allahabad M.Sc.? - 2002
Projects & Funding
Projects & funding information is unavailable.
Publications (79)
- Plasmon-assisted spectrophotometric determination of calcium ions in water using Acacia nilotica-mediated gold nanoparticles Save
- Molecular modelling and structure-activity relationship of pyrrolo[2,3- d ]pyrimidine derivatives as potent DNA gyrase B inhibitors Save
- An updated review on phytochemical and pharmacological potential of Portulaca oleracea L. Save
- Thiazepine‐Based Hybrids as Promising Anti‐Colon Cancer Agents: Design, Synthesis, Computational and In Vitro Screening Save
- Development of Novel 1,2,3‐Triazole‐Benzoxazole Hybrids as an E. coli DNA Gyrase B Inhibitor: Design, Synthesis, in Silico, and in Vitro Antimicrobial Evaluation Save
- Benzimidazole and piperidine containing novel 1,2,3‐triazole hybrids as anti‐infective agents: Design, synthesis, in silico and in vitro antimicrobial efficacy Save
- Molecular modeling and biological investigation of novel s-triazine linked benzothiazole and coumarin hybrids as antimicrobial and antimycobacterial agents Save
- Development of novel thiazole-based hybrids as DNA gyrase inhibitors: design, synthesis, in silico and in vitro antibacterial evaluation Save
- Design, synthesis, molecular docking, molecular dynamic simulation, and MMGBSA analysis of 7-O-substituted 5-hydroxy flavone derivatives Save
- Synthesis, characterization, molecular dynamic simulation, and biological assessment of cinnamates linked to imidazole/benzimidazole as a CYP51 inhibitor Save