VENKATA RAO KAKI
NIPER Hyderabad, National Institute of Pharmaceutical Education and Research Hyderabad, Central University of Punjab
0000-0002-2840-861X
About
My research primarily focuses on the discovery and development of novel anti-inflammatory and anti-proliferative agents, integrating both synthetic chemistry and computational approaches. Current investigations include the design and synthesis of selenated heterocycles, selenazolines, and berberine derivatives as potential kinase inhibitors and MMP-9 inhibitors. New synthetic methodologies have been developed to access these bioactive compounds efficiently. In parallel, efforts are underway to develop scalable synthetic processes for active pharmaceutical ingredients (APIs), including Melitracin and other Grignard reaction-based products. Additionally, I am exploring the therapeutic potential of natural product extracts, with a particular emphasis on elucidating their anti-inflammatory mechanisms through network pharmacology.
Employment
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NIPER Hyderabad Associate Professor2025 - Present
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National Institute of Pharmaceutical Education and Research Hyderabad Assistant Professor2020 - 2025
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Central University of Punjab Assistant Professor2016 - 2020
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International Medical University Lecturer-III2014 - 2016
Education
Education history is unavailable.
Projects & Funding
Projects & funding information is unavailable.
Publications (22)
- Addressing the selectivity challenge in matrix metalloproteinases: fragment-based design of MMP-9 inhibitors targeting the S1′ pocket Save
- Exploring the Potential Targets and Elucidating the Molecular Mechanisms Underlying the Anti-inflammatory Activity of Plectranthus amboinicus (Karpuravalli) in the Arachidonic Acid Metabolic Pathway by Network Pharmacology, Molecular Docking and Experime… Save
- ‘Dawa-ul-kurkum’, a Potential Anti-Diabesity Polyherbal Formulation: Phyto-Metabolomics, Network Pharmacology, Molecular Docking and Simulation Studies Supported by in vitro Activity Save
- Sustainable synthesis of melitracen HCl and its key intermediate, 10,10-Dimethylanthrone: A green solvent-driven and economically efficient approach with comprehensive sustainability analysis using iGAL 2.0 Save
- Understanding Molecular Mechanisms Behind the Anti-Inflammatory Effects of Machilus macrantha (Gulmavu) by Network Pharmacology and Molecular Modeling Approach Save
- Sustainability at scale: implementing a green solvent approach for Grignard reactions in the synthesis of key intermediates for Active Pharmaceutical Ingredients (APIs) Save
- Towards sustainable and scalable synthesis of amitriptyline hydrochloride, minoxidil, and pyrrolidinyl diaminopyrimidine oxide Save
- Selective C3 Functionalization of 4H‐Pyrido[1,2‐a]pyrimidin‐4‐Ones via Glyoxylic Acid: Tuning Products with Temperature and Solvents Save
- A validated, precise TLC-densitometry method for simultaneous quantification of mahanimbine and koenimbine in marketed herbal formulations Save
- Development of trisubstituted thiophene-3-arboxamide selenide derivatives as novel EGFR kinase inhibitors with cytotoxic activity Save