RR

Rajdeep Roy

Presidency University

ORCID iD 0000-0002-2911-6694
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About

RAJDEEP ROY, PhD
Cancer Biology | Molecular Oncology | Translational Cancer Research
Email: [email protected] | Phone: +91 7980104341
Professional Profile
PhD-trained cancer biologist with expertise in molecular oncology, cancer immunology, drug resistance, CRISPR/Cas9 genome editing, RNA sequencing, mammalian cell culture, molecular biology and translational cancer research. Experienced in independent project execution, scientific writing, data analysis and multidisciplinary collaborations.
Research Interests
My research focuses on understanding the molecular mechanisms that regulate tumor progression, therapeutic resistance, autophagy, inflammation, and tumor–microenvironment interactions, with the goal of identifying novel therapeutic targets for precision oncology. I am particularly interested in integrating molecular biology, functional genomics, and genome-editing approaches to decipher the signaling networks that influence cancer development and treatment response.
Core Technical Expertise
 Molecular cloning, CRISPR
 Immunofluorescence microscopy
 Co-immunoprecipitation
 Western Blot
 RT-PCR
 Immunohistochemistry
 Animal cell culture
 In-vivo mice model
 In-silico data analysis
 Microbiology techniques
 Molecular biology techniques
 Research methodology
 Laboratory management
 Scientific writing
Professional Experience
Current position, ICMR- Research Project Assistant, “Exploring the role XIAP and FLIP in the activation of Inflammasomes for the better understanding of the inflammasome mediated Lung Carcinogenesis” – Presidency University
Doctoral Researcher | Presidency University | 2020–2025
Investigated molecular mechanisms of Imatinib resistance in Chronic Myeloid Leukemia through molecular, cellular and transcriptomic approaches. Performed RNA-seq analysis, signalling pathway validation, and translational studies using patient samples.
Previous Work Experience
• Research Scholar, IIEST Shibpur – Glioblastoma research (03/2017 - 01/2019)
• Senior Research Fellow, ICAR-CTCRI (06/2016 - 01/2017)
• Junior Research Fellow, Regional Plant Resource Centre (05/2015 - 05/2016)
• Guest Lecturer, Ravenshaw University (01/2014 - 05/2015)
• Automed System – Bangalore 02/2011- 09/2013

Selected Publications
1. Roy R, Haldar A, Das PK, Biswas N.
Post-treatment tumor immune microenvironment and the dual role of myeloid-derived suppressor cells (MDSCs) in cancer progression and therapeutic resistance.
Critical Reviews in Oncology/Hematology, Volume 221, 2026, 105148, ISSN 1040-8428
DOI: https://doi.org/10.1016/j.critrevonc.2026.105148
2. Roy R, Paul T, Das PK, Sinha S, Ray SS, Bhattacharyya M, Biswas N.
ERK-mTOR crosstalk suppresses autophagy and upregulates proteasomal degradation pathway to confer Chronic Myeloid Leukemia cells resistant to Imatinib.
Experimental Hematology, 2025, 105330
DOI: https://doi.org/10.1016/j.exphem.2025.105330
3. Paul T, Roy R, Sarkar RD, Sinha S, Biswas N.
H2O2 mediated FLIP and XIAP down-regulation involves increased ITCH expression and ERK-Akt crosstalk in imatinib resistant Chronic Myeloid Leukemia cell line K562.
Free Radical Biology and Medicine, Volume 166, 2021, 265-276
DOI: https://doi.org/10.1016/j.freeradbiomed.2021.02.024
4. Roy R, Das T, Biswas N.
Orchestration of immune response by innate lymphoid cell subtype 2 at various tumor microenvironment, a suitable target for cancer immunotherapy.
International Reviews of Immunology, Volume 43(2), 2024, 74-82
DOI: https://doi.org/10.1080/08830185.2023.2247021
5. Sinha S, Roy R, Barman N, Sarkar P, Saha A, Biswas N.
IL6 mediated cFLIP downregulation increases the migratory and invasive potential of triple negative breast cancer cell.
Cellular Signalling, Volume 130, 2025, 111679
DOI: https://doi.org/10.1016/j.cellsig.2025.111679
6. Bandyopadhyay A, Sinha S, Roy R, et al.
Autophagy mediated immune response regulation and drug resistance in cancer.
Molecular Biology Reports, Volume 52, 2025, 492
DOI: https://doi.org/10.1007/s11033-025-10573-5
Education
• PhD – Presidency University
• MSc Biotechnology – Bangalore University
• BSc Microbiology – Vidyasagar University
National Exam Qualification
• CSIR, UGC-NET (JRF), 12/01/17
• CSIR, UGC-NET (LS), 06/01/17, 12/01/16, 06/01/15, 12/01/12
Workshops & Hands-on Training
• Coding for Biologists – 30-Day Hands-on Training Program, Biotechnika, November 2024.
• Workshop on Flow Cytometry – Organized by Bio-Rad Laboratories, Presidency University, Kolkata, August 2019.
• Winter School on Minimally Invasive Biopsy in Cancer – National Institute of Biomedical Genomics (NIBMG), Kalyani, West Bengal, December 2017.
• National Workshop on Application of Bioinformatics in Medical Research – Regional Medical Research Centre (RMRC), Bhubaneswar, February 2015.
National & International conference presentations
• International Meeting IABS 2025, Indian Association for the Cultivation of Science (IACS), Kolkata – Poster Presentation: 'An Interdisciplinary Approach to Biologica

Employment

  • Presidency University PhD
    2020 - 2025

Education

  • Presidency University PhD
    2020 - 2026

Projects & Funding

Projects & funding information is unavailable.

Publications (6)