SONIYA RANI
GITAM University, Maharishi Markandeshwar University, Mullana, Babasaheb Bhimrao Ambedkar University, Uttarakhand Technical University
0000-0002-3093-9938
About
I, Dr. Soniya Rani, Assistant Professor, in the Department of Pharmacology, GITAM School of Pharmacy, GITAM (Deemed to be University), Hyderabad-campus, Telangana, India.
I have successfully completed my Ph.D. in Pharmacology from Babasaheb Bhimrao Ambedkar University (BBAU), Lucknow under the guidance of Dr Gaurav Kaithwas at Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow. Recently, We are working on hypoxia associated regulation of malignancies. Hypoxia-inducible factor-1alpha (HIF-1α) is a major transcription factor that adapts to low oxygen homeostasis and regulates the expression of several hypoxic genes, which aid in cancer survival and development. It has recently piqued the interest of translational researchers in the disciplines of cancer sciences. Hypoxia triggers an ample adaptive mechanism mediated via the HIF-1α transcriptional domain. Anaerobic glycolysis, angiogenesis, metastasis, and mitophagy are adaptive mechanisms that support tumor survival by promoting oxygen supply and regulating oxygen demand in hypoxic tumor cells. Throughout this pathway, the factor-inhibiting HIF-1α is a negative regulator of HIF-1α leading to its hydroxylation at the C-TAD domain of HIF-1α under normoxia. Thus, hydroxylated HIF-1α is unable to proceed with the transcriptional events due to interference in binding of C-TAD and CBP/p300.
Employment
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GITAM University Assistant Professor2024 - Present
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Maharishi Markandeshwar University, Mullana Assistant Professor2024 - 2024
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Babasaheb Bhimrao Ambedkar University PhD Research Scholar2018 - 2024
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Sardar Patel Post Graduate Institute of Dental and Medical Sciences Lecturer2018 - 2018
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Doon Group of Colleges Assistant Professor2017 - 2018
Education
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Babasaheb Bhimrao Ambedkar University PhD2018 - 2024
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Babasaheb Bhimrao Ambedkar University M.Pharm (Pharmacology)2015 - 2017
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Uttarakhand Technical University B.Pharm2011 - 2015
Projects & Funding
Projects & funding information is unavailable.
Publications (11)
- Maceration phytochemical screening and in vivo neuro-pharmacological evaluations of Rynchotechum Ellipticum acetone fraction in Swiss albino mice Save
- Theoretical and Computational Study of Bioactive Compounds from 𝑀𝑦𝑟𝑖𝑐𝑎 𝑛𝑎𝑔𝑖 as Inhibitors of Neuroendocrine and Opioid Receptors: A Molecular Docking and Dynamics Approach Save
- Metallic Nanocarriers for Targeted Delivery of Anticancer Drugs: Advances and Therapeutic Potential Save
- Efficacy of Novel L-Carnitine/PEG6000-Modified Exemestane Loaded Protein Nanoparticles Against Pre-neoplastic Mammary Damage Save
- A novel quinazoline derivative exhibits potent anticancer cytotoxicity via apoptosis and inhibition of angiogenesis in DMBA‐induced mammary gland carcinoma Save
- In-silico screening of phytochemicals from Tridax procumbens. Linn against human neutrophil elastase targeting chronic obstructive pulmonary disease Save
- Antiproliferative, apoptotic and anti-inflammatory potential of 5H-benzo[h]thiazolo[2,3-b]quinazoline analogues: Novel series of anticancer compounds Save
- Antiproliferative effect of indeno[1,2-d]thiazolo[3,2-a]pyrimidine analogues on IL-6 mediated STAT3 and role of the apoptotic pathway in albino Wistar rats of ethyl carbamate-induced lung carcinoma: In-silico, In-vitro, and In-vivo study Save
- Regulation of Transactivation at C‐TAD Domain of HIF‐1α by Factor‐Inhibiting HIF‐1α (FIH‐1): A Potential Target for Therapeutic Intervention in Cancer Save
- Development of doxorubicin hydrochloride–loaded whey protein nanoparticles and its surface modification with N-acetyl cysteine for triple-negative breast cancer Save