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PREETI SHARMA

City of Hope National Medical Center, Beckman Research Institute of the City of Hope, University of Florence, Indian Institute of Technology Roorkee, TissueGnostics GmbH, Gujarat University

ORCID iD 0000-0002-3254-9546
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About

Postdoctoral Research Scientist at City of Hope | Cancer Immunotherapy | Bispecific T‑Cell Engagers | Hybridoma | Spectral Flow Cytometry | Open to Scientific Opportunities

PROFESSIONAL SUMMARY
Postdoctoral research scientist with 4+ years of experience in T cell engager–based therapeutics, hybridoma based monoclonal antibody generation, immune profiling, and preclinical drug evaluation across multiple myeloma, AL amyloidosis, and AML. Extensive expertise in spectral flow cytometry panel development and in vitro, ex vivo, and in vivo preclinical models. Published first author, contributor to multiple peer-reviewed publications and conference abstracts, and recipient of research awards. Experienced in laboratory operations, trainee mentorship, and multitasking across parallel research projects in collaborative settings.

CORE SCIENTIFIC EXPERTISE
Immuno‑Oncology & Biologics
‣ Bispecific & multivalent T‑cell engagers (CD38, BCMA)
‣ Hybridoma‑based monoclonal antibody generation and screening
‣ ADCC assays, immune synapse evaluation, xCELLigence, IC50 profiling, cytokine profiling
‣ Combination strategies (TCEs, ADCs, proteasome inhibitors, immunomodulators, oncolytic virus)

Preclinical & Translational Research
‣ Human PBMC and patient bone marrow–derived assays
‣ NSG xenograft efficacy studies and PDX model development

Flow Cytometry & Single‑Cell Analysis
‣ Cytek Aurora spectral flow (≥29‑color panels)
‣ FlowJo analysis, gating standardization
‣ Immune phenotyping, resistance mechanism profiling
‣ Single‑cell RNA‑seq (developing)

Molecular & Cell Biology
‣ CRISPR/Cas9 gene editing
‣ Lentiviral packaging & stable cell line generation
‣ Protein and antibody purification, qPCR, ELISA, western blot, viral titration

AWARDS
‣ Oral Presenter and Abstract Achievement Award – ASH (2025)
‣ Marie Skłodowska‑Curie Doctoral Fellowship – European Union Horizon (2016–2019)
‣ ESCEO Eli Lilly Scholarship – World Congress on Osteoporosis & Musculoskeletal Diseases, France (2019)
‣ ASBMR Young Investigator Award – Int. Symp. on Calcium Sensing Receptor, Italy (2017)

Employment

  • City of Hope National Medical Center Postdoctoral Research Fellow - Advancing Cancer Immunotherapy
    2023 - Present
  • Beckman Research Institute of the City of Hope Postdoctoral Research Fellow - Viral Oncology-Epstein–Barr Virus
    2021 - 2023
  • TissueGnostics GmbH Visiting Marie Curie Fellow - PhD Industrial Secondment
    2019 - 2019
  • Medical University of Vienna Visiting Marie Curie Fellow - PhD Research Secondment
    2019 - 2019
  • The University of Manchester Visiting Marie Curie Fellow - PhD Research Secondment
    2019 - 2019
  • Royal Liverpool and Broadgreen University Hospital NHS Trust Visiting Marie Curie Fellow - PhD Clinical Secondment
    2019 - 2019
  • University of Florence Marie Curie PhD Fellow - Calcium Metabolism and Skeletal Muscle Disorders
    2016 - 2020
  • KU Leuven Research Assistant - Molecular Virology- Flavivirus
    2014 - 2015

Education

  • University of Florence PhD in Clinical Science
    2016 - 2020
  • Indian Institute of Technology Roorkee M.Sc. Biotechnology
    2012 - 2014
  • Gujarat University B.Sc. Biotechnology
    2009 - 2012

Projects & Funding

Projects & funding information is unavailable.

Publications (13)