Dr. Perla Ramesh

About

I, Dr. Perla Ramesh, am working in the field of Organic Synthesis, Biotransformations, Drug discovery, and the development of new methods at the Indian Institute of Chemical Technology, Hyderabad. I have developed effective routes to the synthesis of several bioactive molecules and important chiral drug intermediates. I have developed new synthetic methodologies which are simple but effective to obtain enantiomerically pure chiral intermediates. My work explores in detail the various approaches to the problem which include substrate modification, chemical modification of the enzyme, and enzyme immobilization.

Employment

• SRK Degree and PG College Lecturer
  2009 - 2010
• Pratibha Juniour College Lecturer
  2008 - 2009

Education

• Ewha Womans University College of Pharmacy Postdoctoral Research
  2016 - Present
• Indian Institute of Chemical Technology Ph.D.
  2010 - 2015
• Kakatiya Institute of Technology and Science M.Sc
  2006 - 2008
• Government Degree College B.Sc
  2002 - 2006

Projects & Funding

Projects & funding information is unavailable.

Publications (35)

• An Oxidative Palladium-Catalyzed Remote meta–Selective Homo-Biaryl-Coupling Assisted by Nitrile Directing Templates
  2025 DOI: 10.26434/chemrxiv-2025-2mj5p
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• Recyclable Aliphatic Nitrile-Template Enabled Remote meta-C-H Functionalization at Room Temperature.
  The Journal of organic chemistry 2022 DOI: 10.1021/acs.joc.1c02865
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• Development of a Triazolobenzodiazepine-Based PET Probe for Subtype-Selective Vasopressin 1A Receptor Imaging
  Pharmacological Research 2021 DOI: 10.1016/j.phrs.2021.105886
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• A simple removable aliphatic nitrile template 2-cyano-2,2-di-isobutyl acetic acid for remote meta-selective C–H functionalization
  Organic Chemistry Frontiers 2021 DOI: 10.1039/d1qo00140j
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• Development of a triazolobenzodiazepine-based PET probe for subtype-selective vasopressin 1A receptor imaging
  bioRxiv 2021 DOI: 10.1101/2021.02.09.430516
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• Palladium-Catalyzed Aerobic Oxidative Coupling of ortho-(Alkynyl)styrenes with Allylic Alcohols via 6-endo-dig Cyclization: Regioselective Construction of Polysubstituted Naphthalenes
  The Journal of Organic Chemistry 2019 DOI: 10.1021/acs.joc.9b01240
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• Asymmetric Synthetic Strategies of (R)-(–)-Baclofen: An Antispastic Drug
  Synthesis 2018 DOI: 10.1055/s-0036-1590938
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• Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole Molecules
  SynOpen 2018 DOI: 10.1055/s-0036-1591754
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• Design and Synthesis of New Etodolac-Pyridazinones as Potent Anticancer Agents Using Pb(OAc)<inf>4</inf> to Assist N-N Bond Formation
  ChemistrySelect 2018 DOI: 10.1002/slct.201800459
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• A three-step total synthesis of goniothalesdiol A using a one-pot Sharpless epoxidation/regioselective epoxide ring-opening
  Tetrahedron Letters 2017 DOI: 10.1016/j.tetlet.2017.01.100
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