Arghya Mukherjee
Children's Hospital of Philadelphia, University of Pennsylvania, Friedrich Miescher Institute for Biomedical Research, Tufts University
0000-0002-3341-4408
About
Dr. Arghya Mukherjee is a systems neuroscientist whose research focuses on the functional maturation of neural circuits during adolescence and their disruption in neurodevelopmental disorders. His scientific journey began as a University Grants Commission of India-funded research fellow at the Indian Institute of Science Education and Research in Pune, India. Here, Dr. Mukherjee investigated how neuropeptides modulate olfactory sensitivity to align feeding behavior with internal energy states, using zebrafish as a model system.
Pursuing his PhD at the Friedrich Miescher Institute in Switzerland, with Professor Pico Caroni, Dr. Mukherjee explored the neural circuit mechanisms across the prefrontal cortex and hippocampus that support rule learning and memory consolidation. His work identified a sensitive period in early adulthood for long-lasting restoration of prefrontal inhibitory drive and associated rule learning deficits in a genetic mouse model of schizophrenia.
Following his PhD, Dr. Mukherjee moved to the United States for postdoctoral research at MIT and later at Tufts University. There, he uncovered cell-type-specific frontothalamic circuits that support decision-making under uncertainty and established tree shrews, a phylogenetic intermediate between primates and rodents, as a model for dissecting cognitive control circuits. Dr. Mukherjee's postdoctoral work was funded by a Y. Eva Tan Postdoctoral fellowship and a K99/R00 Pathway to Independence award.
In 2025, Dr. Mukherjee joined the Center for Brain Research in Development, Genetics, and Engineering (BRIDGE) at the Children's Hospital of Philadelphia and the University of Pennsylvania as an assistant professor. His research is supported by funding from the National Institute of Mental Health, the BRIDGE Center, and CHOP.
Employment
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Children's Hospital of Philadelphia Senior Principal Scientist2025 - Present
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University of Pennsylvania Assistant Professor2025 - Present
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Tufts University Postdoctoral Scholar2023 - 2025
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Massachusetts Institute of Technology Postdoctoral Associate2019 - 2023
Education
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Friedrich Miescher Institute for Biomedical Research Ph.D.2011 - 2019
Projects & Funding
Projects & funding information is unavailable.
Publications (15)
- From genetic predisposition to mental health: Human cortical development in vitro Save
- Prefrontal transthalamic uncertainty processing drives flexible switching Save
- Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility Save
- A conserved cell-type gradient across the human mediodorsal and paraventricular thalamus Save
- Thalamocortical architectures for flexible cognition and efficient learning Save
- The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia Save
- EXCITATORY NEURONS IN HUMAN MEDIODORSAL THALAMUS ARE IMPLICATED IN GENETIC RISK FOR SERIOUS MENTAL ILLNESS Save
- Sensitivity of olfactory sensory neurons to food cues is tuned to nutritional states by Neuropeptide Y signaling Save
- Thalamic circuits for independent control of prefrontal signal and noise Save
- Variation of connectivity across exemplar sensory and associative thalamocortical loops in the mouse Save