Murali Subramani

About

Retinal ganglion cells (RGCs) are the main output neurons that wire the retina with higher centers of the brain for the perception of vision. Degeneration of these cells in glaucoma patients disrupts this wiring leading to irreversible loss. Ex-vivo stem cell therapy for glaucomatous degeneration is a practical approach whose success depends upon transplanted human RGCs’ ability to elaborate axons that can read guidance cues and connect properly with the central targets. However, whether or not the hRGCs recruit similar mechanisms to find the central targets is not well understood. Here, we have examined if hRGCs are capable of reading the cues within the retina to orient their axons toward the optic disc for a proper exit, the first step toward connecting with the central targets.

Employment

• University of Nebraska Medical Center Postdoctoral Research Associate
  2021 - Present
• Eyestem research Pvt Ltd Research Scientist
  2019 - 2019
• Narayana Nethralaya Research Associate
  2008 - 2019
• Sri Baba Minerals Microbiologist
  2007 - 2008

Education

• Jamal Mohamed College, Bharathidasan University PhD
  2014 - 2019
• Don Bosco Institute of Bioscience Master of Science
  2004 - 2006
• Government Science College Bachlor of Science
  2000 - 2003

Projects & Funding

Projects & funding information is unavailable.

Publications (25)

• Disease modeling of myocilin mutation-dependent normal tension glaucoma: human retinal ganglion cell susceptibility to unfolded protein response and mTOR signaling
  Stem Cells 2026 DOI: 10.1093/stmcls/sxag009
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• Human Retinal Ganglion Cells Respond to Evolutionarily Conserved Chemotropic Cues for Intra Retinal Guidance and Regeneration
  Stem Cells 2023 DOI: 10.1093/stmcls/sxad061
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• Correlation between tear levels of vascular endothelial growth factor and vitamin D at retinopathy of prematurity stages in preterm infants.
  Scientific reports 2023 DOI: 10.1038/s41598-023-43338-w
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• Reproducible generation of human retinal ganglion cells from banked retinal progenitor cells: analysis of target recognition and IGF-1-mediated axon regeneration
  Frontiers in Cell and Development Biology 2023
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• Human Retinal Ganglion Cells Respond to Evolutionarily Conserved Chemotropic Cues for Intra Retinal Guidance and Regeneration
  2023 DOI: 10.1101/2023.02.01.526677
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• Microglia: Friends or Foes in Glaucoma? A Developmental Perspective
  Stem Cells Translational Medicine 2022 DOI: 10.1093/stcltm/szac077
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• Safety and efficacy of combination of suberoylamilide hydroxyamic acid and mitomycin C in reducing pro-fibrotic changes in human corneal epithelial cells.
  Scientific reports 2021 DOI: 10.1038/s41598-021-83881-y
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• Resveratrol Rescues Human Corneal Epithelial Cells Cultured in Hyperosmolar Conditions: Potential for Dry Eye Disease Treatment.
  Cornea 2020 DOI: 10.1097/ico.0000000000002495
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• Fiber Diameter Differentially Regulates Function of Retinal Pigment and Corneal Epithelial Cells on Nanofibrous Tissue Scaffolds.
  ACS applied bio materials 2020 DOI: 10.1021/acsabm.9b00897
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• Vitamin-D3 (α-1, 25(OH) 2D3) Protects Retinal Pigment Epithelium From Hyperoxic Insults.
  Investigative ophthalmology & visual science 2020 DOI: 10.1167/iovs.61.2.4
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