Sonam Raj

About

I completed PhD research in 2018 at Banaras Hindu University, India, where I discovered novel mutations, in addition to known mutations, in Indian PKD patients and corelated their genotype to phenotype. I validated role of the genetic variants identified in PKD patients with disease pathogenesis. For this work, I was awarded with best poster presentation award by Indian society of Human genetics. My research works have been recognized by reputed international journals. After Ph.D., I joined Mayo Clinic as visiting fellow where I worked on finding mosaicism in rare cases of polycystic kidney disease which has been published in Kidney international journal. From the project, I gained experience in whole genome sequencing analysis. I am personally interested to understand and develop new therapeutic approaches in prostate cancer, and I am fortunate to receive this opportunity to join as a visiting Fellow in Dr. Kelly lab, NCI, NIH in 2019. I am working in a project entitled “Identifying viability factors in prostate cancer to develop better therapeutic targets”. I am working with patient-derived organoids that model the genomic and phenotypic landscape of clinical CRPC and developed novel protocols for CRISPR screening in these models.

Employment

• National Cancer Institute Post Doctoral Fellow
  2019 - Present

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (6)

• The Megacomplex protects ER-alpha from degradation by Fulvestrant in epithelial ovarian cancer
  Cancer Letters 2025 DOI: 10.1016/j.canlet.2024.217129
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• Metabolic and imaging phenotypes associated with RB1 and TP53 loss in prostate cancer
  2023 DOI: 10.1101/2023.11.15.567250
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• Developmental Acquisition of p53 Functions
  Genes 2021 DOI: 10.3390/genes12111675
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• Detection and characterization of mosaicism in autosomal dominant polycystic kidney disease
  Kidney International 2020 DOI: 10.1016/j.kint.2019.08.038
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• Mutational screening of PKD1 and PKD2 in Indian ADPKD patients identified 95 genetic variants
  Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 2020 DOI: 10.1016/j.mrfmmm.2020.111718
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• Mutational screening of PKD2 gene in the north Indian polycystic kidney disease patients revealed 28 genetic variations
  Journal of Genetics 2017 DOI: 10.1007/s12041-017-0824-5
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