Jia-Xuan Chen

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Publications (32)

• Interplay of the ENS and Microbiota With Murine Gut Epithelium-Derived Organoids in Aging.
  Aging cell 2026 DOI: 10.1111/acel.70608
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• The Host Cell Factor Phosphatase-2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type-1.
  Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 DOI: 10.1002/advs.202523697
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• Graphene Triggers Inflammation in Murine Microglia via Phagocytosis.
  Small science 2026 DOI: 10.1002/smsc.202500531
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• Identification of a Proteolysis-Targeting-Chimera that Addresses Activated Checkpoint Kinase-1 Reveals its Non-Catalytic Functions in Tumor Cells.
  Angewandte Chemie (International ed. in English) 2025 DOI: 10.1002/anie.202514788
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• Structural basis for DNA break sensing by human MRE11-RAD50-NBS1 and its regulation by telomeric factor TRF2.
  Nature communications 2025 DOI: 10.1038/s41467-025-64082-x
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• The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells.
  Leukemia 2025 DOI: 10.1038/s41375-025-02612-8
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• Poly-GR Impairs PRMT1-Mediated Arginine Methylation of Disease-Linked RNA-Binding Proteins by Acting as a Substrate Sink.
  Biochemistry 2024 DOI: 10.1021/acs.biochem.4c00308
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• The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence.
  Nucleic acids research 2024 DOI: 10.1093/nar/gkae426
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• Activation and Purification of ß-Glucocerebrosidase by Exploiting its Transporter LIMP-2 - Implications for Novel Treatment Strategies in Gaucher's and Parkinson's Disease.
  Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 DOI: 10.1002/advs.202401641
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• The Proteomic Composition and Organization of Constitutive Heterochromatin in Mouse Tissues.
  Cells 2024 DOI: 10.3390/cells13020139
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• Ubiquiton-An inducible, linkage-specific polyubiquitylation tool.
  Molecular cell 2023 DOI: 10.1016/j.molcel.2023.11.016
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• K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution.
  Molecular cell 2023 DOI: 10.1016/j.molcel.2023.10.011
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• Designing photoaffinity tool compounds for the investigation of the DENV NS2B-NS3 protease allosteric binding pocket.
  RSC medicinal chemistry 2023 DOI: 10.1039/d3md00331k
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• Proteome changes of fibroblasts and endothelial cells upon incubation with human cytomegalovirus subviral Dense Bodies.
  Scientific data 2023 DOI: 10.1038/s41597-023-02418-2
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• Cell-of-origin-specific proteomics of extracellular vesicles.
  PNAS nexus 2023 DOI: 10.1093/pnasnexus/pgad107
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• HMGXB4 Targets Sleeping Beauty Transposition to Germinal Stem Cells.
  International journal of molecular sciences 2023 DOI: 10.3390/ijms24087283
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• Structural mechanism of extranucleosomal DNA readout by the INO80 complex.
  Science advances 2022 DOI: 10.1126/sciadv.add3189
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• Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules.
  eLife 2021 DOI: 10.7554/elife.60833
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• Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences.
  PLoS genetics 2021 DOI: 10.1371/journal.pgen.1009600
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• Centriolar satellites are acentriolar assemblies of centrosomal proteins.
  The EMBO journal 2019 DOI: 10.15252/embj.2018101082
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