Matteo Castelli
University of California San Diego, University of Pavia, University of Milan
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Aortic Disease and Treatment Approaches · Protein Structure and Dynamics · Aortic Thrombus and Embolism
0000-0002-3673-0262
About
Organic chemist by formation, currently Postdoctoral Researcher in computational chemistry and biophysics at UCSD - Amaro Lab. Experience in computer simulations of biological systems with interest in allosteric mechanism and free energy landscape. Consolidated expertise in integrative structural biology and related drug design applications. Positive attitude to teamwork and advanced communication skills.
Employment
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University of California, San Diego Postdoctoral Researcher2023 - Present
Education
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Università degli Studi di Pavia PhD Student2020 - 2023
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Università degli Studi di Pavia Master Degree2018 - 2020
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Università degli Studi di Milano Bachelor Degree2015 - 2018
Projects & Funding
Projects & funding information is unavailable.
Publications (24)
- ReVesicle: Curation and Equilibration of Lipid Vesicles for Mesoscale Simulations Save
- Meso-Soup: A community approach to building a computational description of the biological mesoscale Save
- Design of multi-target peptide modulators for protein chaperone networks Save
- Disulfide-mediated tetramerization of TRAP1 fosters its antioxidant and pro-neoplastic activities Save
- Decrypting Allostery in Membrane-Bound K-Ras4B Using Complementary In Silico Approaches Based on Unbiased Molecular Dynamics Simulations Save
- Disulfide-mediated tetramerization of TRAP1 fosters its antioxidant and pro-neoplastic activities. Save
- Molecular mechanisms of chaperone-directed protein folding: Insights from atomistic simulations Save
- N-Glycosylation-Induced Pathologic Protein Conformations as a Tool to Guide the Selection of Biologically Active Small Molecules Save
- Structures, dynamics, complexes, and functions: From classic computation to artificial intelligence Save
- How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view Save
- PhosY-secretome profiling combined with kinase-substrate interaction screening defines active c-Src-driven extracellular signaling Save
- Phosphorylation of the Hsp90 Co-Chaperone Hop Changes its Conformational Dynamics and Biological Function Save
- AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity Save
- Decrypting the languages of allostery in membrane-bound K-Ras4B using four complementary in silico approaches Save
- It takes two to tango: Change in the quaternary structure and oncogenicity of TRAP1 via cysteine oxidation Save
- NLRP3 monomer Functional Dynamics: from the Effects of Allosteric Binding to Implications for Drug Design Save
- NLRP3 monomer functional dynamics: From the effects of allosteric binding to implications for drug design Save
- Studying the Dynamics of a Complex G-Quadruplex System: Insights into the Comparison of MD and NMR Data Save
- Protein Allostery and Ligand Design: Computational Design Meets Experiments to Discover Novel Chemical Probes Save
- A Single Post-Translational Modification with Far-Reaching Effects on the Assembly of a Multiprotein Chaperone Complex: A Mechanistic View from the Integration of Computation and Experiments Save