0000-0002-3703-3274 About
I am working on two different aspects of environmental issues i.e. Nanotoxicology (toxicity, tumorogenesis and health hazards) and Nanotechnology (pharmacological aspects and cancer treatment with nanoparticles). Presently I am working on the mechanism of cytotoxicity and genotoxicity of Titanium dioxide nanoparticles in invitro and in vivo exposure. I concluded from our research with number of studies that TiO2 nanoparticles has hazardous effects on kidney, liver and brain mainly confirmed with various biomarkers (liver function assay, kidney function assay, oxidative stress markers, apoptosis, DNA strand break, micronuclei and many more). I have studied the comparative toxicity of TiO2 and TiSiO4 nanoparticles in HEK-293 cells and found that TiSiO4 were less toxic and can replace the TiO2 nanoparticle applications.
I have sound expertise in cancer research and developmental biology. As a pharmacological, I used hydroxyapatite (Hap) nanoparticles as a drug to evaluate the effect on human breast cancer cells and also quantify anti-proliferation and p53 protein expression in cancerous cells. It has been found to have obvious inhibitory function on growth of many kinds of tumor cells, and nanoparticle has stronger anti-tumor effect than macromolecule microparticles.
I am interested to implement HAP NPs conjugated with DOX (Chemotherapeutic drugs) and coated with polymer as a targeted drug delivery for slow drug release in vitro and in vivo studies. I have published paper on Effects of hydroxyapatite nanoparticles on proliferation and apoptosis of human breast cancer cells (MCF-7). This is also my interest to develop new criteria of therapeutic impact on affected cells.
Employment
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Jawaharlal Nehru University School of Environmental Sciences Assistant Professor2017 - Present
Education
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Jawaharlal Nehru University School of Environmental Sciences Ph.D.2008 - 2014
Projects & Funding
Projects & funding information is unavailable.
Publications (46)
- Targeted disruption of Biofilm-Associated MDR pathogens using Curcumin-Loaded mesoporous spions Save
- Multifunctional B4C/SnO2 Nanocomposites: A study on antimicrobial activity, photocatalysis, and electrical properties Save
- Nanobiosensors: A Potential Tool to Decipher the Nexus Between SARS-CoV-2 Infection and Gut Dysbiosis Save
- Sustainable agriculture in oman: evaluating treated wastewater irrigation effects on soil quality, heavy metal accumulation, and alfalfa growth Save
- Photocatalytic and Antibacterial NiO/MgO Nanocomposites for Efficient Dyes Removal From Industrial Wastewater Save
- Bovine serum albumin-chitosan nanoparticles loaded with Cordyceps militaris extract: A novel approach to combat MDR bacteria Save
- Molecular Weights of Polyethyleneimine-Dependent Physicochemical Tuning of Gold Nanoparticles and FRET-Based Turn-On Sensing of Polymyxin B Save
- Effect of differential deprivation of nutrients on cellular proliferation, oxidative stress, mitochondrial function, and cell migration in MDA-MB-231, HepG2, and HeLa cells Save
- Divergent Responses of Hydrophilic CdSe and CdSe@CdS Core–Shell Nanocrystals in Apoptosis and In Vitro Cancer Cell Imaging: A Comparative Analysis Save
- Synthesis and Spectral Characterisation of Fabricated Cerium-Doped Magnesium Oxide Nanoparticles: Evaluation of the Antimicrobial Potential and Its Membranolytic Activity through Large Unilamellar Vesicles Save