Elizabeth Thomas

Employment

• University of Maryland

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (14)

• Formation of multiple G-quadruplexes contributes toward BCR fragility associated with chronic myelogenous leukemia.
  Nucleic acids research 2025 DOI: 10.1093/nar/gkaf167
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• Thermal proteome profiling and proteome analysis using high-definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next-generation galeterone analog VNPP433-3β in castration-resistant prostate cancer.
  Molecular oncology 2025 DOI: 10.1002/1878-0261.70009
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• VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins in vitro and in vivo by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2.
  Frontiers in oncology 2023 DOI: 10.3389/fonc.2023.1240996
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• Salinization Dramatically Enhance the Anti-Prostate Cancer Efficacies of AR/AR-V7 and Mnk1/2 Molecular Glue Degraders, Galeterone and VNPP433-3β Which Outperform Docetaxel and Enzalutamide in CRPC CWR22Rv1 Xenograft Mouse Model.
  Bioorganic chemistry 2023 DOI: 10.1016/j.bioorg.2023.106700
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• Targeted Degradation of Androgen Receptor by VNPP433-3β in Castration-Resistant Prostate Cancer Cells Implicates Interaction with E3 Ligase MDM2 Resulting in Ubiquitin-Proteasomal Degradation.
  Cancers 2023 DOI: 10.3390/cancers15041198
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• Murine toxicology and pharmacokinetics of lead next generation galeterone analog, VNPP433-3β.
  Steroids 2023 DOI: 10.1016/j.steroids.2023.109184
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• Novel AR/AR-V7 and Mnk1/2 Degrader, VNPP433-3β: Molecular Mechanisms of Action and Efficacy in AR-Overexpressing Castration Resistant Prostate Cancer In Vitro and In Vivo Models.
  Cells 2022 DOI: 10.3390/cells11172699
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• Large-scale synthesis of galeterone and lead next generation galeterone analog VNPP433-3β.
  Steroids 2022 DOI: 10.1016/j.steroids.2022.109062
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• Novel deuterated Mnk1/2 protein degrader VNLG-152R analogs: Synthesis, In vitro Anti-TNBC activities and pharmacokinetics in mice.
  European journal of medicinal chemistry 2022 DOI: 10.1016/j.ejmech.2022.114441
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• Transcriptome profiling reveals that VNPP433-3β, the lead next-generation galeterone analog inhibits prostate cancer stem cells by downregulating epithelial-mesenchymal transition and stem cell markers.
  Molecular carcinogenesis 2022 DOI: 10.1002/mc.23406
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