Abhishek Gupta
The University of Texas Health Science Center at San Antonio, Ohio University, Central Drug Research Institute
0000-0002-3932-2512
About
Currently I am working at Joe R. & Teresa Lozano Long School of Medicine at University of Texas, Health Science Center, San Antonio, Texas, USA with Dr. Peng Zhao and Dr. Xiaoli Sun. Zhao/Sun lab work on metabolic diseases including obesity, diabetes, NAFLD and atherosclerosis. My primary research focus involves identification of novel pathways in the pathogenesis of obesity and diabetes.
Prior to joining UT Heath, Texas, I was working with Dr. Vishwajeet Puri at OHIO University, where my studies were focused on elucidating the critical role of human FSP27 gene in regulating lipid homeostasis in adipose tissue. We developed an innovative mouse model expressing single allele of either full length or mutated human FSP27 transgene specifically in mouse adipocytes. We mechanistically deciphered the contribution of FSP27 towards systemic insulin sensitivity, glucose metabolism, energy homeostasis and lipid turnover.
Apart from lab's research interest, I explored and identified two novel gene candidates playing an important role adipocyte lipid homeostasis. Function of both the genes are not yet identified. In my preliminary studies I identified that one of them functions by regulating PPARg stability and the other gene functions as an important activator of beta-adrenergic receptor. I wish to peruse these studies further.
During my PhD, with Dr. Anil N. Gaikwad at Central Drug Research Institute, India, I worked on type 2 diabetes, encompassing alterations in insulin sensitivity of adipocytes. I worked on 3T3-L1 adipocyte as an in-vitro model. Since adipose tissue is regarded as an active endocrine organ, I studied secretome profile of adipocytes and was interested in evaluating the autocrine effects of a few adipokines. Our studies on leptin identified that leptin in an autocrine manner contributes to insulin resistance phenotype. Further I studied one of the novel gene MS4A1 which was interesting to work with. I worked on MS4A1, modulating its expression by up-regulation and lenti-virus mediated down-regulation in adipocytes to study its adipocyte specific effects. Additionally, being a part of a premier drug research institute, I worked on a synthetic compound, a natural compound and a plant extract, evaluating their effect on adipocyte differentiation and insulin sensitivity.
Employment
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The University of Texas Health Science Center at San Antonio Postdoctoral Researcher2021 - Present
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Ohio University Postdoctoral Researcher2018 - 2021
Education
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Central Drug Research Institute PhD2013 - 2018
Projects & Funding
Projects & funding information is unavailable.
Publications (22)
- Fsp27 plays a crucial role in muscle performance Save
- Coelogin ameliorates metabolic dyshomeostasis by regulating adipogenesis and enhancing energy expenditure in adipose tissue Save
- Ms-275, a class 1 histone deacetylase inhibitor augments glucagon-like peptide-1 receptor agonism to improve glycemic control and reduce obesity in diet-induced obese mice Save
- Role of brown adipose tissue in modulating adipose tissue inflammation and insulin resistance in high-fat diet fed mice. Save
- Identification and quantification of secondary metabolites of Pterocarpus marsupium by LC–MS techniques and its in-vitro lipid lowering activity Save
- CIDE proteins in human health and disease Save
- Chronic hyperinsulinemia induced miR-27b is linked to adipocyte insulin resistance by targeting insulin receptor. Save
- Saroglitazar reduces obesity and associated inflammatory consequences in murine adipose tissue. Save
- Aegeline inspired synthesis of novel β3-AR agonist improves insulin sensitivity in vitro and in vivo models of insulin resistance. Save
- Chronic hyperinsulinemia promotes meta-inflammation and extracellular matrix deposition in adipose tissue: Implications of nitric oxide. Save