Karan KR

About

Kalpita is a postdoctoral research scientist at the Dept. of Psychiatry (Behavioral Medicine), Columbia University, NY. She explores the relationship between mitochondria and the immune system under stress in various model systems. She is extremely keen on translational studies in neurological disorders. Currently, she is involved in a pre-clinical work connecting mitochondrial disease, stress, brain, and epigenetics. She has a Bachelor's degree in Biotechnology and a Master's degree in Medical Genetics from India. She trained in Human Genetics during her Ph.D. in India, where she discovered the contribution of genes in rare sensory epilepsy called Hot water epilepsy in an Indian cohort. Kalpita is motivated by the unknowns in science and their implications in society.

Employment

• Weill Cornell Medicine Research Associate
  2021 - Present
• Columbia University Postdoctoral Scientist
  2017 - 2021
• Jawaharlal Nehru Centre for Advanced Scientific Research Research Associate
  2016 - 2017

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (20)

• Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts
  PLOS Biology 2024 DOI: 10.1371/journal.pbio.3002723
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• Suppression of CNS APOE4 Expression by miRNAs Delivered by the S2 AAVrh.10 Capsid-Modified AAV Vector
  Human Gene Therapy 2024 DOI: 10.1089/hum.2024.112
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• Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging
  Psychoneuroendocrinology 2023 DOI: 10.1016/j.psyneuen.2023.106322
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• OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases
  Communications Biology 2023 DOI: 10.1038/s42003-022-04303-x
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• Corrigendum to “Dynamic behavior of cell-free mitochondrial DNA in human saliva” [Psychoneuroendocrinology 143 (2022) 105852]
  Psychoneuroendocrinology 2022 DOI: 10.1016/j.psyneuen.2022.105884
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• Dynamic behavior of cell-free mitochondrial DNA in human saliva
  Psychoneuroendocrinology 2022 DOI: 10.1016/j.psyneuen.2022.105852
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• Leukocyte cytokine responses in adult patients with mitochondrial DNA defects
  Journal of Molecular Medicine 2022 DOI: 10.1007/s00109-022-02206-2
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• Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological Aging
  2022 DOI: 10.1101/2022.02.22.481548
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• OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases
  2021 DOI: 10.1101/2021.11.29.470428
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• Stress and circulating cell-free mitochondrial DNA: a systematic review of human studies, physiological considerations, and technical recommendations
  Mitochondrion 2021 DOI: 10.1016/j.mito.2021.04.002
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